ArticleJournal of neurophysiology2016
Failure to suppress low-frequency neuronal oscillatory activity underlies the reduced effectiveness of random patterns of deep brain stimulation.
Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Systematic review of rodent studies of deep brain stimulation for the treatment of neurological, developmental and neuropsychiatric disorders.Translational psychiatry · 2024Pooled it
- Low vs high frequency deep brain stimulation for Parkinson's disease-associated motor symptoms: A systematic review and meta-analysis of randomized control trials.Journal of Parkinson's disease · 2026Review
- Pallidothalamic Circuit-Selective Manipulation Ameliorates Motor Symptoms in a Rat Model of Parkinsonian.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Threat gates visual aversion via theta activity in Tachykinergic neurons.Nature communications · 2023Article
- The Therapeutic Frequency Profile of Subthalamic Nucleus Deep Brain Stimulation in Rats Is Shaped by Antidromic Spike Failure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Editorial: Insights into the use of deep brain stimulation as a treatment for Parkinson's disease and related conditions.Frontiers in neuroscience · 2023Article
- Excitatory deep brain stimulation quenches beta oscillations arising in a computational model of the subthalamo-pallidal loop.Scientific reports · 2022Article
- Deep brain stimulation in the subthalamic nucleus for Parkinson's disease can restore dynamics of striatal networks.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The cortical evoked potential corresponds with deep brain stimulation efficacy in rats.Journal of neurophysiology · 2022Article
- [Design and application of neural electrical stimulation system with time-varying parameters].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2021Article
- Adjust Neuronal Reactions to Pulses of High-Frequency Stimulation with Designed Inter-Pulse-Intervals in Rat Hippocampus In Vivo.Brain sciences · 2021Article
- The Effect of Unilateral Subthalamic Nucleus Deep Brain Stimulation on Contralateral Subthalamic Nucleus Local Field Potentials.Neuromodulation : journal of the International Neuromodulation Society · 2020Article
- Frequency-Specific Optogenetic Deep Brain Stimulation of Subthalamic Nucleus Improves Parkinsonian Motor Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Intraoperative Microelectrode Recordings in Substantia Nigra Pars Reticulata in Anesthetized Rats.Frontiers in neuroscience · 2020Article
- Proceedings of the Seventh Annual Deep Brain Stimulation Think Tank: Advances in Neurophysiology, Adaptive DBS, Virtual Reality, Neuroethics and Technology.Frontiers in human neuroscience · 2020Article
- Electrodeposited platinum-iridium coating improves in vivo recording performance of chronically implanted microelectrode arrays.Biomaterials · 2019Article
- Article
- Deep cerebellar stimulation reduces ataxic motor symptoms in the shaker rat.Annals of neurology · 2019Article
- Small Changes in Inter-Pulse-Intervals Can Cause Synchronized Neuronal Firing During High-Frequency Stimulations in Rat Hippocampus.Frontiers in neuroscience · 2019Article
- Patterned low-frequency deep brain stimulation induces motor deficits and modulates cortex-basal ganglia neural activity in healthy rats.Journal of neurophysiology · 2018Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Subthalamic nucleus (STN) deep brain stimulation (DBS) is an established treatment for the motor symptoms of Parkinson's disease (PD). However, the mechanisms of action of DBS are unknown. Random temporal patterns of DBS are less effective than regular DBS, but the neuronal basis for this dependence on temporal pattern of stimulation is unclear. Using a rat model of PD, we quantified the changes in behavior and single-unit activity in globus pallidus externa and substantia nigra pars reticulata during high-frequency STN DBS with different degrees of irregularity. Although all stimulus trains had the same average rate, 130-Hz regular DBS more effectively reversed motor symptoms, including circling and akinesia, than 130-Hz irregular DBS. A mixture of excitatory and inhibitory neuronal responses was present during all stimulation patterns, and mean firing rate did not change during DBS. Low-frequency (7-10 Hz) oscillations of single-unit firing times present in hemiparkinsonian rats were suppressed by regular DBS, and neuronal firing patterns were entrained to 130 Hz. Irregular patterns of DBS less effectively suppressed 7- to 10-Hz oscillations and did not regularize firing patterns. Random DBS resulted in a larger proportion of neuron pairs with increased coherence at 7-10 Hz compared with regular 130-Hz DBS, which suggested that long pauses (interpulse interval >50 ms) during random DBS facilitated abnormal low-frequency oscillations in the basal ganglia. These results suggest that the efficacy of high-frequency DBS stems from its ability to regularize patterns of neuronal firing and thereby suppress abnormal oscillatory neural activity within the basal ganglia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.