ArticleJournal of neurophysiology2016
Unitary synaptic connections among substantia nigra pars reticulata neurons.
Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Synaptic integration and competition in the substantia nigra pars reticulata-An experimental and in silico analysis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dynamic changes in chloride homeostasis coordinate midbrain inhibitory network activity during reward learning.Nature communications · 2025Article
- Impact of Unitary Synaptic Inhibition on Spike Timing in Ventral Tegmental Area Dopamine Neurons.eNeuro · 2024Article
- Propagation of Oscillations in the Indirect Pathway of the Basal Ganglia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Spontaneous Activity of the Local GABAergic Synaptic Network Causes Irregular Neuronal Firing in the External Globus Pallidus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Transmission of delta band (0.5-4 Hz) oscillations from the globus pallidus to the substantia nigra pars reticulata in dopamine depletion.Journal of computational neuroscience · 2022Article
- Local inhibition in a model of the indirect pathway globus pallidus network slows and deregularizes background firing, but sharpens and synchronizes responses to striatal input.Journal of computational neuroscience · 2022Article
- Dissociable Roles of Pallidal Neuron Subtypes in Regulating Motor Patterns.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Periodic unitary synaptic currents in the mouse globus pallidus during spontaneous firing in slices.Journal of neurophysiology · 2021Article
- Neural activity during a simple reaching task in macaques is counter to gating and rebound in basal ganglia-thalamic communication.PLoS biology · 2020Article
- Article
- Cellular and Synaptic Dysfunctions in Parkinson's Disease: Stepping out of the Striatum.Cells · 2019Review
- Population dynamics and entrainment of basal ganglia pacemakers are shaped by their dendritic arbors.PLoS computational biology · 2019Article
- Predicting responses to inhibitory synaptic input in substantia nigra pars reticulata neurons.Journal of neurophysiology · 2018Article
- Associative and sensorimotor cortico-basal ganglia circuit roles in effects of abused drugs.Genes, brain, and behavior · 2017Review
- Mechanisms of Network Interactions for Flexible Cortico-Basal Ganglia-Mediated Action Control.eNeuroArticle
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2 authors at 1 institution in 1 country.
Funding
Abstract
Neurons in substantia nigra pars reticulata (SNr) are synaptically coupled by local axon collaterals, providing a potential mechanism for local signal processing. Because SNr neurons fire spontaneously, these synapses are constantly active. To investigate their properties, we recorded spontaneous inhibitory postsynaptic currents (sIPSCs) from SNr neurons in brain slices, in which afferents from upstream nuclei are severed, and the cells fire rhythmically. The sIPSC trains contained a mixture of periodic and aperiodic events. Autocorrelation analysis of sIPSC trains showed that a majority of cells had one to four active unitary inputs. The properties of the unitary IPSCs (uIPSCs) were analyzed for cells with one unitary input, using a model of periodic presynaptic firing and stochastic synaptic transmission. The inferred presynaptic firing rates and coefficient of variation of interspike intervals (ISIs) corresponded well with direct measurements of spiking in SNr neurons. Methods were developed to estimate the success probability, amplitude distributions, and kinetics of the uIPSCs, while removing the contribution from aperiodic sIPSCs. The sIPSC amplitudes were not increased upon release from halorhodopsin silencing, suggesting that most synapses were not depressed at the spontaneous firing rate. Gramicidin perforated-patch recordings indicated that the average reversal potential of spontaneous inhibitory postsynaptic potentials was -64 mV. Because of the change in driving force across the ISI, the unitary inputs are predicted to have a larger postsynaptic impact when they arrive late in the ISI. Simulations of network activity suggest that this very sparse inhibitory coupling may act to desynchronize the activity of SNr neurons while having only a small effect on firing rate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.