ArticleProceedings of the National Academy of Sciences of the United States of America2016
Response of single bacterial cells to stress gives rise to complex history dependence at the population level.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Diverse drought responses and evidence for stress priming in glacier-fed stream bacteria.Frontiers in microbiology · 2026Article
- Diversification of single-cell growth dynamics under starvation influences subsequent reproduction in a clonal bacterial population.The ISME journal · 2025Article
- Climate history modulates stress responses of common soil bacteria under experimental drought.The ISME journal · 2025Article
- Article
- Phenotypic memory in quorum sensing.PLoS computational biology · 2024Article
- Microfluidic approaches in microbial ecology.Lab on a chip · 2024Review
- Ecological success of extreme halophiles subjected to recurrent osmotic disturbances is primarily driven by congeneric species replacement.The ISME journal · 2024Article
- Interspecies interactions determine growth dynamics of biopolymer-degrading populations in microbial communities.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Phenotypic heterogeneity in the bacterial oxidative stress response is driven by cell-cell interactions.Cell reports · 2023Article
- Changes in interactions over ecological time scales influence single-cell growth dynamics in a metabolically coupled marine microbial community.The ISME journal · 2023Article
- Rare and localized events stabilize microbial community composition and patterns of spatial self-organization in a fluctuating environment.The ISME journal · 2022Article
- Probabilistic Inference with Polymerizing Biochemical Circuits.Entropy (Basel, Switzerland) · 2022Article
- A localized DNA finite-state machine with temporal resolution.Science advances · 2022Article
- A Peptide Derived from GAPDH Enhances Resistance to DNA Damage in Saccharomyces cerevisiae Cells.Applied and environmental microbiology · 2022Article
- Characterizing Natural Organic Matter Transformations by Microbial Communities in Terrestrial Subsurface Ecosystems: A Critical Review of Analytical Techniques and Challenges.Frontiers in microbiology · 2022Review
- Nutrient Gradients Mediate Complex Colony-Level Antibiotic Responses in Structured Microbial Populations.Frontiers in microbiology · 2022Article
- The cost of bacterial predation via type VI secretion system leads to predator extinction under environmental stress.iScience · 2021Article
- Causes and consequences of pattern diversification in a spatially self-organizing microbial community.The ISME journal · 2021Article
- Review
- Nongenetic individuality, changeability, and inheritance in bacterial behavior.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Most bacteria live in ever-changing environments where periods of stress are common. One fundamental question is whether individual bacterial cells have an increased tolerance to stress if they recently have been exposed to lower levels of the same stressor. To address this question, we worked with the bacterium Caulobacter crescentus and asked whether exposure to a moderate concentration of sodium chloride would affect survival during later exposure to a higher concentration. We found that the effects measured at the population level depended in a surprising and complex way on the time interval between the two exposure events: The effect of the first exposure on survival of the second exposure was positive for some time intervals but negative for others. We hypothesized that the complex pattern of history dependence at the population level was a consequence of the responses of individual cells to sodium chloride that we observed: (i) exposure to moderate concentrations of sodium chloride caused delays in cell division and led to cell-cycle synchronization, and (ii) whether a bacterium would survive subsequent exposure to higher concentrations was dependent on the cell-cycle state. Using computational modeling, we demonstrated that indeed the combination of these two effects could explain the complex patterns of history dependence observed at the population level. Our insight into how the behavior of single cells scales up to processes at the population level provides a perspective on how organisms operate in dynamic environments with fluctuating stress exposure.
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