ArticleAmerican journal of epidemiology2016
Temporal Relationship Between Elevated Blood Pressure and Arterial Stiffening Among Middle-Aged Black and White Adults: The Bogalusa Heart Study.
Article in American journal of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005129 (The Bogalusa Heart Study), which is not on this map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Bogalusa Heart Study
Who cites it
40 citing papers in PubMed, 64 citations in OpenAlex.
- Total cholesterol, arterial stiffness, and systolic blood pressure: a mediation analysis.Scientific reports · 2021Trial
- Age- and Sex-Specific Patterns of Arterial Stiffness Assessed by Cardio-Ankle Vascular Index in Apparently Healthy Chinese Adults: A Cross-Sectional Study.Metabolites · 2026Article
- The effects of Songling Xuemaikang capsule on vascular remodeling of stage 1 hypertension: a multicenter, randomized placebo-controlled trial protocol.BMC complementary medicine and therapies · 2025Article
- Temporal and joint associations of hypertension and estimated pulse wave velocity with incident cardiovascular diseases: a population-based cohort study.European journal of medical research · 2025Article
- Cross-sectional and longitudinal trajectory analyses of sleep duration and frailty among middle-aged and older Chinese adults.Scientific reports · 2025Article
- Blood Pressure Mediates the Association Between Visceral-to-Subcutaneous Fat Ratio and Arterial Stiffness in Patients With Type 2 Diabetes.Journal of diabetes research · 2025Article
- Age and blood pressure stratified healthy vascular aging, organ damage and prognosis in the community-dwelling elderly: insights from the North Shanghai Study.Clinical hypertension · 2024Article
- Temporal relationships between blood glucose, lipids and BMI, and their impacts on atherosclerosis: a prospective cohort study.BMJ open · 2024Article
- Temporal relationship between arterial stiffness and blood pressure variability and joint effect on cardiovascular disease.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Temporal and Bidirectional Association Between Blood Pressure Variability and Arterial Stiffness: Cross-Lagged Cohort Study.JMIR public health and surveillance · 2023Article
- Relative Contribution of Blood Pressure in Childhood, Young- and Mid-Adulthood to Large Artery Stiffness in Mid-Adulthood.Journal of the American Heart Association · 2022Article
- Association Between Plasma Fibulin-1 and Brachial-Ankle Pulse Wave Velocity in Arterial Stiffness.Frontiers in cardiovascular medicine · 2022Article
- Blood Pressure Trajectories From Childhood to Youth and Arterial Stiffness in Adulthood: A 30-Year Longitudinal Follow-Up Study.Frontiers in cardiovascular medicine · 2022Article
- The Relationship Between Sleep Duration and Blood Lipids Among Chinese Middle-Aged and Older Adults: Cross-Lagged Path Analysis From CHARLS.Frontiers in public health · 2022Article
- Association Between Blood Pressure Control and Arterial Stiffness in Middle-Aged and Elderly Chinese Patients with Hypertension.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Temporal Relationship Between Changes in Serum Calcium and Hypercholesteremia and Its Impact on Future Brachial-Ankle Pulse Wave Velocity Levels.Frontiers in nutrition · 2021Article
- Mediating Effect of Body Mass Index and Dyslipidemia on the Relation of Uric Acid and Type 2 Diabetes: Results From China Health and Retirement Longitudinal Study.Frontiers in public health · 2021Article
- Challenges and Opportunities for the Prevention and Treatment of Cardiovascular Disease Among Young Adults: Report From a National Heart, Lung, and Blood Institute Working Group.Journal of the American Heart Association · 2020Review
- Genetic aetiology of blood pressure relates to aortic stiffness with bi-directional causality: evidence from heritability, blood pressure polymorphisms, and Mendelian randomization.European heart journal · 2020Article
- Can atherosclerosis be cured?Current opinion in lipidology · 2019Review
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Authors and funding
9 authors.
Funding
Abstract
This study assessed the temporal relationship between elevated blood pressure (BP) and arterial stiffness in a biracial (black-white) cohort of middle-aged adults aged 32-51 years from the semirural community of Bogalusa, Louisiana. Measurements of aortic-femoral pulse wave velocity (afPWV; n = 446) and large- and small-arterial compliance (n = 381) were obtained at 2 time points between 2000 and 2010, with an average follow-up period of 7 years. A cross-lagged path analysis model was used to examine the temporal relationship of elevated BP to arterial stiffness and elasticity. The cross-lagged path coefficients did not differ significantly between blacks and whites. The path coefficient (ρ2) from baseline BP to follow-up afPWV was significantly greater than the path coefficient (ρ1) from baseline afPWV to follow-up BP (ρ2 = 0.20 vs. ρ1 = 0.07 (P = 0.048) for systolic BP; ρ2 = 0.19 vs. ρ1 = 0.05 (P = 0.034) for diastolic BP). The results for this 1-directional path from baseline BP to follow-up afPWV were confirmed, although marginally significant, by using large- and small-artery elasticity measurements. These findings provide strong evidence that elevated BP precedes large-artery stiffening in middle-aged adults. Unlike the case in older adults, the large-arterial wall is not stiff enough in youth to alter BP levels during young adulthood.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.