Evidence map›Paper›PMID 26960695›Full record

ArticleScientific reports2016

Intracellular nanoparticles mass quantification by near-edge absorption soft X-ray nanotomography.

Jose Javier Conesa, Joaquín Otón, Michele Chiappi, Jose María Carazo, Eva Pereiro, Francisco Javier Chichón, José L Carrascosa

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  4. Towards a quantitative theory for transmission X-ray microscopy.Beilstein journal of nanotechnology · 2025
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  8. Quantitative, in situ visualization of intracellular insulin vesicles in pancreatic beta cells.Proceedings of the National Academy of Sciences of the United States of America · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jose Javier ConesaCentro Nacional de Biotecnología (CNB-CSIC), Cantoblanco, 28049 Madrid, Spain.
Joaquín OtónCentro Nacional de Biotecnología (CNB-CSIC), Cantoblanco, 28049 Madrid, Spain.
Michele ChiappiCentro Nacional de Biotecnología (CNB-CSIC), Cantoblanco, 28049 Madrid, Spain.
Jose María CarazoCentro Nacional de Biotecnología (CNB-CSIC), Cantoblanco, 28049 Madrid, Spain.
Eva PereiroALBA Synchrotron Light Source, MISTRAL Beamline - Experiments Division, 08290 Cerdanyola del Vallès, Barcelona, Spain.
Francisco Javier ChichónCentro Nacional de Biotecnología (CNB-CSIC), Cantoblanco, 28049 Madrid, Spain.
José L CarrascosaCentro Nacional de Biotecnología (CNB-CSIC), Cantoblanco, 28049 Madrid, Spain.
Centro Nacional de Biotecnología · ESALBA Synchrotron (Spain) · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We used soft X-ray three-dimensional imaging to quantify the mass of superparamagnetic iron oxide nanoparticles (SPION) within whole cells, by exploiting the iron oxide differential absorption contrast. Near-edge absorption soft X-ray nanotomography (NEASXT) combines whole-cell 3D structure determination at 50 nm resolution, with 3D elemental mapping and high throughput. We detected three-dimensional distribution of SPIONs within cells with 0.3 g/cm(3) sensitivity, sufficient for detecting the density corresponding to a single nanoparticle.

Indexed as

Metal NanoparticlesHumansMCF-7 CellsX-Ray Microtomography

Identifiers

PMID26960695
PMCPMC4785355
OpenAlexW2295053754

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.