ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016
miR-522 contributes to cell proliferation of hepatocellular carcinoma by targeting DKK1 and SFRP2.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Wnt signaling in cancer: from biomarkers to targeted therapies and clinical translation.Molecular cancer · 2025Review
- Review
- Long non‑coding RNA LINC00238 suppresses the malignant phenotype of liver cancer by sponging miR‑522.Molecular medicine reports · 2022Article
- Drug Discovery of DKK1 Inhibitors.Frontiers in pharmacology · 2022Review
- Review
- The Dickkopf1 and FOXM1 positive feedback loop promotes tumor growth in pancreatic and esophageal cancers.Oncogene · 2021Article
- Circular RNA expression profiles in the plasma of patients with infantile hemangioma determined using microarray analysis.Experimental and therapeutic medicine · 2021Article
- Targeting of ΔNp63α by miR-522 promotes the migration of breast epithelial cells.FEBS open bio · 2021Article
- Genome-Wide Screening Identifies Prognostic Long Noncoding RNAs in Hepatocellular Carcinoma.BioMed research international · 2021Article
- Chronic liquid fructose supplementation does not cause liver tumorigenesis but elicits clear sex differences in the metabolic response in Sprague-Dawley rats.Food & nutrition research · 2021Article
- Circular RNAs: pivotal molecular regulators and novel diagnostic and prognostic biomarkers in non-small cell lung cancer.Journal of cancer research and clinical oncology · 2019Review
- miR-522 facilitates the prosperities of endometrial carcinoma cells by directly binding to monoamine oxidase B.The Kaohsiung journal of medical sciences · 2019Article
- miR-522-3p Promotes Tumorigenesis in Human Colorectal Cancer via Targeting Bloom Syndrome Protein.Oncology research · 2018Article
- Interplay of miRNAs and Canonical Wnt Signaling Pathway in Hepatocellular Carcinoma.Frontiers in pharmacology · 2018Article
- Expression of EZH2 in endometrial carcinoma and its effects on proliferation and invasion of endometrial carcinoma cells.Oncology letters · 2017Article
- miR-92a promotes hepatocellular carcinoma cells proliferation and invasion by FOXA2 targeting.Iranian journal of basic medical sciences · 2017Article
- Several microRNAs could predict survival in patients with hepatitis B-related liver cancer.Scientific reports · 2017Article
- The role of Dickkopf family in cancers: from Bench to Bedside.American journal of cancer research · 2017Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The morbidity and mortality of hepatocellular carcinoma (HCC) is very high, finding new therapeutic targets are critical for HCC treatment. miR-522 has been demonstrated to be upregulated in HCC tissues, but its role in HCC progression remains to be elucidated. In this report, we found miR-522 was upregulated in HCC cells and tissues, miR-522 overexpression promoted cell proliferation, colony formation, and cell cycle progression, whereas knockdown of miR-522 reduced these effects. We also analyzed the expression of several key cell cycle regulatory proteins and found overexpression of miR-522-inhibited cell cycle inhibitors p21 and p27 expression and enhanced cyclin D1 expression and the level of Rb phosphorylation, vice versa. These suggested miR-522-accelerated G1/S transition. DKK1 (dickkopf-1) and SFRP2 (secreted frizzled-related protein 2) were the targets of miR-522, their expression was inversely with miR-522 in HCC tissues. DKK1 and SFRP2 the antagonists of Wnt signaling, suggesting miR-522-promoted HCC progression through activating Wnt signaling. miR-522 might be a valuable target for HCC therapy.
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