ArticleBone2016
Parathyroid hormone attenuates radiation-induced increases in collagen crosslink ratio at periosteal surfaces of mouse tibia.
Article in Bone, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Prediction of biomechanical properties of ex vivo human femoral cortical bone using Raman spectroscopy and machine learning algorithms.Bone reports · 2025Article
- Evaluation of radiation therapy on grafted and non-grafted defects: an experimental rat model.Journal of applied oral science : revista FOB · 2025Article
- Long-duration type 1 diabetes is associated with deficient cortical bone mechanical behavior and altered matrix composition in human femoral bone.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- The effects of BPA-BNCT on normal bone: determination of the CBE value in mice‡.Journal of radiation research · 2023Article
- Relative Effects of Radiation-Induced Changes in Bone Mass, Structure, and Tissue Material on Vertebral Strength in a Rat Model.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Article
- Collagen cross-link profiles and mineral are different between the mandible and femur with site specific response to perturbed collagen.Bone reports · 2022Article
- Orchestrated delivery of PTH [1-34] followed by zoledronic acid prevents radiotherapy-induced bone loss but does not abrogate marrow damage.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Genetic variability affects the skeletal response to immobilization in founder strains of the diversity outbred mouse population.Bone reports · 2021Article
- Relations Between Bone Quantity, Microarchitecture, and Collagen Cross-links on Mechanics Following In Vivo Irradiation in Mice.JBMR plus · 2021Article
- In Vitro Radiosensitivity of Murine Marrow Stromal Cells Varies Across Donor Strains.Radiation research · 2021Article
- Altered mechanical behavior of demineralized bone following therapeutic radiation.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Radiation-induced changes to bone composition extend beyond periosteal bone.Bone reports · 2020Article
- Review
- Article
- Raman Spectroscopic Analysis to Detect Reduced Bone Quality after Sciatic Neurectomy in Mice.Molecules (Basel, Switzerland) · 2018Article
- Assessing glycation-mediated changes in human cortical bone with Raman spectroscopy.Journal of biophotonics · 2018Article
- Longitudinal Effects of Single Hindlimb Radiation Therapy on Bone Strength and Morphology at Local and Contralateral Sites.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Article
- Limited field radiation therapy results in decreased bone fracture toughness in a murine model.PloS one · 2018Article
- Vibrational spectroscopic techniques to assess bone quality.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
As part of our ongoing efforts to understand underlying mechanisms contributing to radiation-associated bone fragility and to identify possible treatments, we evaluated the longitudinal effects of parathyroid hormone (PTH) treatment on bone quality in a murine model of limited field irradiation. We hypothesized PTH would mitigate radiation-induced changes in the chemical composition and structure of bone, as measured by microscope-based Raman spectroscopy. We further hypothesized that collagen crosslinking would be especially responsive to PTH treatment. Raman spectroscopy was performed on retrieved tibiae (6-7/group/time point) to quantify metrics associated with bone quality, including: mineral-to-matrix ratio, carbonate-to-phosphate ratio, mineral crystallinity, collagen crosslink (trivalent:divalent) ratio, and the mineral and matrix depolarization ratios. Irradiation disrupted the molecular structure and orientation of bone collagen, as evidenced by a higher collagen crosslink ratio and lower matrix depolarization ratio (vs. non-irradiated control bones), persisting until 12weeks post-irradiation. Radiation transiently affected the mineral phase, as evidenced by increased mineral crystallinity and mineral-to-matrix ratio at 4weeks compared to controls. Radiation decreased bone mineral depolarization ratios through 12weeks, indicating increased mineral alignment. PTH treatment partially attenuated radiation-induced increases in collagen crosslink ratio, but did not restore collagen or mineral alignment. These post-radiation matrix changes are consistent with our previous studies of radiation damage to bone, and suggest that the initial radiation damage to bone matrix has extensive effects on the quality of tissue deposited thereafter. In addition to maintaining bone quality, preventing initial radiation damage to the bone matrix (i.e. crosslink ratio, matrix orientation) may be critical to preventing late-onset fragility fractures.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.