Evidence map›Paper›PMID 26960250›Full record

ArticleScientific reports2016

In vivo cross-sectional imaging of the phonating larynx using long-range Doppler optical coherence tomography.

Carolyn A Coughlan, Li-Dek Chou, Joseph C Jing, Jason J Chen, Swathi Rangarajan, Theodore H Chang, Giriraj K Sharma, Kyoungrai Cho, Donghoon Lee, Julie A Goddard and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  4. Phase-resolved dynamic wavefront imaging of cilia metachronal waves.Quantitative imaging in medicine and surgery · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. A computational study of depth of vibration into vocal fold tissues.The Journal of the Acoustical Society of America · 2019
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Carolyn A CoughlanDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, School of Medicine University of California, Irvine, CA, United States.
Li-Dek ChouBeckman Laser Institute &Medical Clinic, University of California, Irvine, CA, United States.
Joseph C JingBeckman Laser Institute &Medical Clinic, University of California, Irvine, CA, United States.
Jason J ChenBeckman Laser Institute &Medical Clinic, University of California, Irvine, CA, United States.
Swathi RangarajanOCT Medical Imaging Inc., University of California, Irvine, CA, United States.
Theodore H ChangOCT Medical Imaging Inc., University of California, Irvine, CA, United States.
Giriraj K SharmaDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, School of Medicine University of California, Irvine, CA, United States.
Kyoungrai ChoBeckman Laser Institute &Medical Clinic, University of California, Irvine, CA, United States.
Donghoon LeeBeckman Laser Institute &Medical Clinic, University of California, Irvine, CA, United States.
Julie A GoddardDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, School of Medicine University of California, Irvine, CA, United States.
Zhongping ChenBeckman Laser Institute &Medical Clinic, University of California, Irvine, CA, United States.
Brian J F WongDepartment of Otolaryngology-Head and Neck Surgery, University of California, Irvine, School of Medicine University of California, Irvine, CA, United States.
University of California, Irvine · USBeckman Laser Institute and Medical Clinic · USOCT Medical Imaging (United States) · US

Funding

Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI DURKIN, ANTHONY · 2012 to 2017
$7.0M
Phase resolved ARF optical coherence elastography for intravascular imagingR01HL125084 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, ZHOU, QIFA · 2014 to 2023
$5.6M
Modeling the Pediatric Upper Airway using A-OCT and Computational Fluid DynamicsR01HL105215 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, ELGHOBASHI, SAID E. · 2010 to 2013
$3.7M
Diagnosis of Subglottic Stenosis and Edema in Neonates Using OCTR01HL103764 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI WONG, BRIAN · 2010 to 2014
$3.1M
Combined OCT/US/PAT system for intravascular ImagingR01HL127271 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, PATEL, PRANAV · 2015 to 2018
$2.7M
Office based real-time high speed 3D-OCT system for diagnosis of early laryngealR44CA177064 · NCI · OCT MEDICAL IMAGING, INC. · PI RAMALINGAM, TIRUNELVELI · 2013 to 2014
$1.9M
3D Real-time imaging system for Subglottic Stenosis and Edema in NeonatesR43HD071701 · NICHD · OCT MEDICAL IMAGING, INC. · PI RAMALINGAM, TIRUNELVELI · 2012 to 2013
$632k
NCI NIH HHS R44 CA177064NCI NIH HHS R44CA177064NHLBI NIH HHS R01 HL103764NHLBI NIH HHS R01 HL105215NHLBI NIH HHS R01HL105215NHLBI NIH HHS R01 HL125084NHLBI NIH HHS R01HL125084NHLBI NIH HHS R01 HL127271NHLBI NIH HHS R01HL127271NIBIB NIH HHS P41 EB015890NIBIB NIH HHS P41EB015890NICHD NIH HHS R43 HD071701NICHD NIH HHS R43HD071701
6 · The paper itself

Abstract

Diagnosis and treatment of vocal fold lesions has been a long-evolving science for the otolaryngologist. Contemporary practice requires biopsy of a glottal lesion in the operating room under general anesthesia for diagnosis. Current in-office technology is limited to visualizing the surface of the vocal folds with fiber-optic or rigid endoscopy and using stroboscopic or high-speed video to infer information about submucosal processes. Previous efforts using optical coherence tomography (OCT) have been limited by small working distances and imaging ranges. Here we report the first full field, high-speed, and long-range OCT images of awake patients' vocal folds as well as cross-sectional video and Doppler analysis of their vocal fold motions during phonation. These vertical-cavity surface-emitting laser source (VCSEL) OCT images offer depth resolved, high-resolution, high-speed, and panoramic images of both the true and false vocal folds. This technology has the potential to revolutionize in-office imaging of the larynx.

Indexed as

HumansLaryngoscopyTomography, Optical CoherenceVocal Cord DysfunctionVocal Cords

Identifiers

PMID26960250
PMCPMC4785353
OpenAlexW2411949542

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.