Evidence map›Paper›PMID 26960195›Full record

Trial reportPloS one2016

A Pilot Randomized Placebo Controlled Trial of Electroacupuncture for Women with Pure Stress Urinary Incontinence.

Huanfang Xu, Baoyan Liu, Jiani Wu, Ruosang Du, Xiaoxu Liu, Jinna Yu, Zhishun Liu

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02445573 (A Pilot Randomized Placebo Controlled Trial of Electroacupuncture for Women With Pure Stress Urinary Incontinence), which is not on this map. Cited by 22 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 10 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02445573 nacompletednot on this map

A Pilot Randomized Placebo Controlled Trial of Electroacupuncture for Women With Pure Stress Urinary Incontinence

TypeinterventionalSponsorGuang'anmen Hospital of China Academy of Chinese Medical SciencesRan2012 to 2014Enrolled80ConditionsStress Urinary IncontinenceArmsEA, sham EA
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 10 syntheses or guidelines pooled it, 37 citations in OpenAlex.

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  7. Acupuncture for treating overactive bladder in adults.The Cochrane database of systematic reviews · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Huanfang XuDepartment of acupuncture and moxibustion, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Baoyan LiuDepartment of acupuncture and moxibustion, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Jiani WuDepartment of acupuncture and moxibustion, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Ruosang DuDepartment of acupuncture and moxibustion, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Xiaoxu LiuDepartment of acupuncture and moxibustion, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Jinna YuDepartment of acupuncture and moxibustion, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Zhishun LiuDepartment of acupuncture and moxibustion, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNBeijing University of Chinese Medicine · CNGuang’anmen Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcupuncture is a potential conservative therapy for women with stress urinary incontinence (SUI). There is limited evidence to support its effectiveness due to the poor quality of existing studies.

methodsWe performed a pilot randomized, controlled trial to preliminarily assess the efficacy of electroacupuncture (EA) in women with pure SUI. A total of 80 women with pure SUI were randomly assigned to receive EA with deep needling at BL33 and BL35 (n = 40) or sham EA with non-penetrating needling at sham acupoints (n = 40) three sessions per week for 6 weeks. The women were followed for 24 weeks. The primary outcome was the change from baseline in the amount of urine leakage measured by a 1-hour pad test after 6 weeks. The secondary outcomes included the 72-hour incontinence episode frequency (IEF), International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF) score, and patient self-evaluation of therapeutic effect. Adverse events (AEs) were monitored throughout the trial.

resultsThe median decrease from baseline of urine leakage measured by the 1-hour pad test was 2.5 g [interquartile range (IQR): 1.80-14.6 in the EA group, which was greater than the median decrease of 0.05 g (IQR: -2.80-+0.50) in the sham EA group after 6 weeks (p<0.01). The differences between groups in the decrease from baseline of 72-hour IEF became statistically significant at week 30 with a median decrease of 3.25 g (IQR: 1.25-5.69) in the EA group, and a median decrease of 1.00 g (IQR: -0.69-+2.88) in the sham EA group (p = 0.01). The participants in the EA group showed greater decreases in ICIQ-SF score and higher ratings in the help they received from the treatment than those in the sham EA group at weeks 6,18 and 30 (all p<0.05). No obvious AEs were observed in either group.

conclusionEA may effectively and safely relieve urinary incontinence symptoms and improve quality of life in women with pure SUI. EA demonstrated more than a placebo effect. Since this is a pilot study, results should be interpreted with caution.

trial registrationClinicalTrials.gov NCT02445573.

Indexed as

ElectroacupunctureDemographyFemaleHumansMiddle AgedPilot ProjectsPlacebo EffectTreatment OutcomeUrinary Incontinence, Stress

Identifiers

PMID26960195
PMCPMC4784883
OpenAlexW2293720901

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.