ArticlePLoS biology2016
Invagination of Ectodermal Placodes Is Driven by Cell Intercalation-Mediated Contraction of the Suprabasal Tissue Canopy.
Article in PLoS biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 56 citations in OpenAlex.
- Mechanical control in dental and jaw morphogenesis and remodeling.International journal of oral science · 2026Review
- Asymmetry of sonic hedgehog expression is necessary for early incisor tooth morphogenesis.Development (Cambridge, England) · 2026Article
- The Rho GTPase regulator ARHGEF3 orchestrates hair placode budding by coordinating cell fate and P-cadherin patterning in mice.PLoS biology · 2026Article
- Reciprocal folding dynamics in cellular networks at the stroma-basement membrane interface.Acta biomaterialia · 2025Article
- Cap-to-bell stage molar tooth morphogenesis occurs through proliferation-independent sulcus sharpening and condensation-associated tension in the dental papilla.Journal of anatomy · 2025Article
- Radially patterned morphogenesis of murine hair follicle placodes ensures robust epithelial budding.Developmental cell · 2024Article
- ARHGEF3 Regulates Hair Follicle Morphogenesis.bioRxiv : the preprint server for biology · 2024Article
- Myosin II mediates Shh signals to shape dental epithelia via control of cell adhesion and movement.PLoS genetics · 2024Article
- Adult dental epithelial stem cell-derived organoids deposit hydroxylapatite biomineral.International journal of oral science · 2023Article
- Using Ex Vivo Live Imaging to Investigate Cell Divisions and Movements During Mouse Dental Renewal.Journal of visualized experiments : JoVE · 2023Article
- Tooth number abnormality: from bench to bedside.International journal of oral science · 2023Review
- Understanding the development of oral epithelial organs through single cell transcriptomic analysis.Development (Cambridge, England) · 2022Article
- The conundrum of pharyngeal teeth origin: the role of germ layers, pouches, and gill slits.Biological reviews of the Cambridge Philosophical Society · 2022Review
- Cellular mechanisms of reverse epithelial curvature in tissue morphogenesis.Frontiers in cell and developmental biology · 2022Review
- Two-Photon Cell and Tissue Level Laser Ablation Methods to Study Morphogenetic Biomechanics.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Cell influx and contractile actomyosin force drive mammary bud growth and invagination.The Journal of cell biology · 2021Article
- Early perturbation of Wnt signaling reveals patterning and invagination-evagination control points in molar tooth development.Development (Cambridge, England) · 2021Article
- FACEts of mechanical regulation in the morphogenesis of craniofacial structures.International journal of oral science · 2021Review
- Intertwined Signaling Pathways Governing Tooth Development: A Give-and-Take Between Canonical Wnt and Shh.Frontiers in cell and developmental biology · 2021Review
- Multiple epithelia are required to develop teeth deep inside the pharynx.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Ectodermal organs such as teeth, hair follicles, and mammary glands begin their development as placodes. These are local epithelial thickenings that invaginate into mesenchymal space. There is currently little mechanistic understanding of the cellular processes driving the early morphogenesis of these organs and of why they lead to invagination rather than simple tissue thickening. Here, we show that placode invagination depends on horizontal contraction of superficial layers of cells that form a shrinking and thickening canopy over underlying epithelial cells. This contraction occurs by cell intercalation and is mechanically coupled to the basal layer by peripheral basal cells that extend apically and centripetally while remaining attached to the basal lamina. This process is topologically analogous to well-studied apical constriction mechanisms, but very different from them both in scale and molecular mechanism. Mechanical cell-cell coupling is propagated through the tissue via E-cadherin junctions, which in turn depend on tissue-wide tension. We further present evidence that this mechanism is conserved among different ectodermal organs and is, therefore, a novel and fundamental morphogenetic motif widespread in embryonic development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.