Evidence map›Paper›PMID 26959868›Full record

ArticleAnalytical chemistry2016

Separation and Identification of Isomeric Glycans by Selected Accumulation-Trapped Ion Mobility Spectrometry-Electron Activated Dissociation Tandem Mass Spectrometry.

Yi Pu, Mark E Ridgeway, Rebecca S Glaskin, Melvin A Park, Catherine E Costello, Cheng Lin

Open access · greenAbstract read
In one paragraph

Article in Analytical chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
16.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 124 citations in OpenAlex.

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  19. Identification ofThe Analyst · 2022
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  20. Effective discrimination of gas-phase peptide conformers using TIMS-ECD-ToF MS/MS.Analytical methods : advancing methods and applications · 2021
    Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yi PuCenter for Biomedical Mass Spectrometry, Boston University School of Medicine , Boston, Massachusetts 02118, United States.
Mark E RidgewayBruker Daltonics , Billerica, Massachusetts 01821, United States.
Rebecca S GlaskinCenter for Biomedical Mass Spectrometry, Boston University School of Medicine , Boston, Massachusetts 02118, United States.
Melvin A ParkBruker Daltonics , Billerica, Massachusetts 01821, United States.
Catherine E CostelloCenter for Biomedical Mass Spectrometry, Boston University School of Medicine , Boston, Massachusetts 02118, United States.
Cheng LinCenter for Biomedical Mass Spectrometry, Boston University School of Medicine , Boston, Massachusetts 02118, United States.
Boston University · USBruker (United States) · US

Funding

XI INTERNATIONAL SYMPOSIUM ON AMYLOIDOSISP41RR010888 · NCRR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ZAIA, JOSEPH · 1996 to 2011
$18.6M
Mass Spectrometry Resource for Biology and MedicineP41GM104603 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COSTELLO, CATHERINE E. · 2012 to 2017
$10.4M
LTQ-FT MS System for On-line Protein and Glycan AnalysisS10RR025082 · NCRR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COSTELLO, CATHERINE E. · 2009 to 2009
$1.3M
NCRR NIH HHS P41 RR010888NCRR NIH HHS S10 RR025082NIGMS NIH HHS P41 GM104603
6 · The paper itself

Abstract

One of the major challenges in structural characterization of oligosaccharides is the presence of many structural isomers in most naturally occurring glycan mixtures. Although ion mobility spectrometry (IMS) has shown great promise in glycan isomer separation, conventional IMS separation occurs on the millisecond time scale, largely restricting its implementation to fast time-of-flight (TOF) analyzers which often lack the capability to perform electron activated dissociation (ExD) tandem MS analysis and the resolving power needed to resolve isobaric fragments. The recent development of trapped ion mobility spectrometry (TIMS) provides a promising new tool that offers high mobility resolution and compatibility with high-performance Fourier transform ion cyclotron resonance (FTICR) mass spectrometers when operated under the selected accumulation-TIMS (SA-TIMS) mode. Here, we present our initial results on the application of SA-TIMS-ExD-FTICR MS to the separation and identification of glycan linkage isomers.

Indexed as

Fourier AnalysisIsomerismMass SpectrometryPolysaccharidesPolysaccharides

Identifiers

PMID26959868
PMCPMC4821751
OpenAlexW2293801117

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.