ArticleAging2016
Measuring aging rates of mice subjected to caloric restriction and genetic disruption of growth hormone signaling.
Article in Aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Rapamycin, Not Metformin, Mirrors Dietary Restriction-Driven Lifespan Extension in Vertebrates: A Meta-Analysis.Aging cell · 2025Pooled it
- DELTA: Strengthening human biological resilience with an N=1 digital health and dynamic biomarker protocol.PloS one · 2026Trial
- Article
- Unveiling ceramide dynamics: Shedding light on healthy aging in growth hormone-releasing hormone knockout mice.Aging cell · 2024Article
- Somatotropic Axis, Pace of Life and Aging.Frontiers in endocrinology · 2022Review
- Growth hormone and aging.Reviews in endocrine & metabolic disorders · 2021Review
- Growth Hormone Deficiency: Health and Longevity.Endocrine reviews · 2019Review
- Growth Hormone and Aging: Updated Review.The world journal of men's health · 2019Review
- Aging research using the common marmoset: Focus on aging interventions.Nutrition and healthy aging · 2019Article
- Impact of Growth Hormone-Related Mutations on Mammalian Aging.Frontiers in genetics · 2018Review
- Article
- Can FSH influence longevity?Aging cell · 2017Article
- Prolonged Growth Hormone/Insulin/Insulin-like Growth Factor Nutrient Response Signaling Pathway as a Silent Killer of Stem Cells and a Culprit in Aging.Stem cell reviews and reports · 2017Review
- Identification of tissue-specific transcriptional markers of caloric restriction in the mouse and their use to evaluate caloric restriction mimetics.Aging cell · 2017Article
- Article
- Article
- GH and ageing: Pitfalls and new insights.Best practice & research. Clinical endocrinology & metabolism · 2017Review
- Computational Analysis of Lifespan Experiment Reproducibility.Frontiers in genetics · 2017Article
- Somatic growth, aging, and longevity.NPJ aging and mechanisms of disease · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Caloric restriction and genetic disruption of growth hormone signaling have been shown to counteract aging in mice. The effects of these interventions on aging are examined through age-dependent survival or through the increase in age-dependent mortality rates on a logarithmic scale fitted to the Gompertz model. However, these methods have limitations that impede a fully comprehensive disclosure of these effects. Here we examine the effects of these interventions on murine aging through the increase in age-dependent mortality rates on a linear scale without fitting them to a model like the Gompertz model. Whereas these interventions negligibly and non-consistently affected the aging rates when examined through the age-dependent mortality rates on a logarithmic scale, they caused the aging rates to increase at higher ages and to higher levels when examined through the age-dependent mortality rates on a linear scale. These results add to the debate whether these interventions postpone or slow aging and to the understanding of the mechanisms by which they affect aging. Since different methods yield different results, it is worthwhile to compare their results in future research to obtain further insights into the effects of dietary, genetic, and other interventions on the aging of mice and other species.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.