ArticlePloS one2016
Long Term Recordings with Immobile Silicon Probes in the Mouse Cortex.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 89 citations in OpenAlex.
- Density-based longitudinal neuron tracking in high-density electrophysiological recordings.Patterns (New York, N.Y.) · 2026Article
- Tantalum Interconnect Metallization for Thin-Film Neural Interface Devices.Micromachines · 2026Article
- Temporal coding carries more stable cortical visual representations than firing rate over time.Nature communications · 2025Article
- Article
- Population imaging of internal state circuits relevant to psychiatric disease: a review.Neurophotonics · 2025Review
- An adaptable, reusable, and light implant for chronic Neuropixels probes.bioRxiv : the preprint server for biology · 2024Article
- Planar amorphous silicon carbide microelectrode arrays for chronic recording in rat motor cortex.Biomaterials · 2024Article
- Large scale, simultaneous, chronic neural recordings from multiple brain areas.bioRxiv : the preprint server for biology · 2024Article
- Impact of Impedance Levels on Recording Quality in Flexible Neural Probes.Sensors (Basel, Switzerland) · 2024Article
- Brain-machine interface learning is facilitated by specific patterning of distributed cortical feedback.Science advances · 2023Article
- Electrophysiology of Laminar Cortical Activity in the Common Marmoset.Journal of visualized experiments : JoVE · 2023Article
- Multilayer Arrays for Neurotechnology Applications (MANTA): Chronically Stable Thin-Film Intracortical Implants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Multi-area recordings and optogenetics in the awake, behaving marmoset.Nature communications · 2023Article
- Translating Pathological Brain Activity Primers in Parkinson's Disease Research.Research (Washington, D.C.) · 2023Review
- From End to End: Gaining, Sorting, and Employing High-Density Neural Single Unit Recordings.Frontiers in neuroinformatics · 2022Review
- Scalable batch fabrication of ultrathin flexible neural probes using a bioresorbable silk layer.Microsystems & nanoengineering · 2022Article
- Cellular activity in insular cortex across seconds to hours: Sensations and predictions of bodily states.Neuron · 2021Review
- Intracortical Microelectrode Array Unit Yield under Chronic Conditions: A Comparative Evaluation.Micromachines · 2021Review
- Representational drift in primary olfactory cortex.Nature · 2021Article
- Neuropixels 2.0: A miniaturized high-density probe for stable, long-term brain recordings.Science (New York, N.Y.) · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A key experimental approach in neuroscience involves measuring neuronal activity in behaving animals with extracellular chronic recordings. Such chronic recordings were initially made with single electrodes and tetrodes, and are now increasingly performed with high-density, high-count silicon probes. A common way to achieve long-term chronic recording is to attach the probes to microdrives that progressively advance them into the brain. Here we report, however, that such microdrives are not strictly necessary. Indeed, we obtained high-quality recordings in both head-fixed and freely moving mice for several months following the implantation of immobile chronic probes. Probes implanted into the primary visual cortex yielded well-isolated single units whose spike waveform and orientation tuning were highly reproducible over time. Although electrode drift was not completely absent, stable waveforms occurred in at least 70% of the neurons tested across consecutive days. Thus, immobile silicon probes represent a straightforward and reliable technique to obtain stable, long-term population recordings in mice, and to follow the activity of populations of well-isolated neurons over multiple days.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.