ArticlePediatric research2016
Clinical associations of immature breathing in preterm infants: part 1-central apnea.
Article in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.
- Body positioning for spontaneously breathing preterm infants with apnoea.The Cochrane database of systematic reviews · 2017Pooled it
- Time spent within the SpOBMJ open respiratory research · 2026Trial
- The effect of nasal olfactory stimulation on apnea of prematurity: a randomized cross-over trial.Pediatric research · 2026Article
- Definitions and monitoring methods for apnea in preterm infants: a scoping review.Pediatric research · 2026Article
- Touchless monitoring of neonatal activity: a multi-center study.Pediatric research · 2026Article
- Dynamic Interactions between the Gut Microbiome, Health, and Metabolic Disorders in Preterm Infants.Journal of microbiology and biotechnology · 2025Review
- Intermittent Hypoxemia and Brain Injury Biomarker S100B in Preterm Infants.medRxiv : the preprint server for health sciences · 2025Article
- Clinical correlates of a high cardiorespiratory risk score for very low birth weight infants.Pediatric research · 2025Article
- Tachycardia-Desaturation Episodes in Neonatal Intensive Care Unit Patients with and without Bronchopulmonary Dysplasia.American journal of perinatology · 2025Article
- Machine Learning Models as Early Warning Systems for Neonatal Infection.Clinics in perinatology · 2025Review
- Continuous non-contact monitoring of neonatal activity.BMC pediatrics · 2025Article
- Apnea, Intermittent Hypoxemia, and Bradycardia Events Predict Late-Onset Sepsis in Infants Born Extremely Preterm.The Journal of pediatrics · 2024Observational
- The impact of intermittent hypoxemia on type 1 retinopathy of prematurity in preterm infants.Pediatric research · 2024Article
- Heart Rate and Pulse Oximetry Dynamics in the First Week after Birth in Neonatal Intensive Care Unit Patients and the Risk of Cerebral Palsy.American journal of perinatology · 2024Article
- Maturation of cardioventilatory physiological trajectories in extremely preterm infants.Pediatric research · 2024Article
- Developmental consequences of short apneas and periodic breathing in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Cardiorespiratory signature of neonatal sepsis: development and validation of prediction models in 3 NICUs.Pediatric research · 2023Article
- The influence of late prematurity on the encephalopathy exam of infants with neonatal encephalopathy.Journal of neonatal-perinatal medicine · 2023Article
- Artificial and human intelligence for early identification of neonatal sepsis.Pediatric research · 2023Review
- Sensory stimulation for apnoea mitigation in preterm infants.Pediatric research · 2022Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundApnea of prematurity (AOP) is nearly universal among very preterm infants, but neither the apnea burden nor its clinical associations have been systematically studied in a large consecutive cohort.
methodsWe analyzed continuous bedside monitor chest impedance and electrocardiographic waveforms and oxygen saturation data collected on all neonatal intensive care unit (NICU) patients <35 wk gestation from 2009 to 2014 (n = 1,211; >50 infant-years of data). Apneas, with bradycardia and desaturation (ABDs), defined as central apnea ≥10 s associated with both bradycardia <100 bpm and oxygen desaturation <80%, were identified using a validated automated algorithm.
resultsNumber and duration of apnea events decreased with increasing gestational age (GA) and postmenstrual age (PMA). ABDs were more frequent in infants <31 wk GA at birth but were not more frequent in those with severe retinopathy of prematurity (ROP), bronchopulmonary dysplasia (BPD), or severe intraventricular hemorrhage (IVH) after accounting for GA. In the day before diagnosis of late-onset septicemia and necrotizing enterocolitis, ABD events were increased in some infants. Many infants continued to experience short ABD events in the week prior to discharge home.
conclusionFrequency of apnea events is a function of GA and PMA in infants born preterm, and increased apnea is associated with acute but not with chronic pathologic conditions.
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Registered trials
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