ArticlePediatric research2016
Altered gene expression and possible immunodeficiency in cases of sudden infant death syndrome.
Article in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Revisiting the association of sudden infant death syndrome (SIDS) with polymorphisms of NHE3 and IL13.International journal of legal medicine · 2024Pooled it
- Review
- The vicious spiral in Sudden Infant Death Syndrome.Frontiers in pediatrics · 2025Review
- Rates of Sudden Unexpected Infant Death Before and During the COVID-19 Pandemic.JAMA network open · 2024Article
- Age-related cytokine imbalance in the thymus in sudden infant death syndrome (SIDS).Pediatric research · 2024Article
- Sudden Infant Death Syndrome (SIDS): State of the Art and Future Directions.International journal of medical sciences · 2024Review
- Pulmonary immune profiling of SIDS: impaired immune maturation and age-related cytokine imbalance.Pediatric research · 2023Article
- Risk of Sudden Infant Death Syndrome Among Siblings of Children Who Died of Sudden Infant Death Syndrome in Denmark.JAMA network open · 2023Article
- Gene expression profile in cases of infectious death in infancy.Pediatric research · 2021Article
- Genetic innovations and our understanding of stillbirth.Human genetics · 2020Review
- Noncardiac genetic predisposition in sudden infant death syndrome.Genetics in medicine : official journal of the American College of Medical Genetics · 2019Article
- A "Wear and Tear" Hypothesis to Explain Sudden Infant Death Syndrome.Frontiers in neurology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA large number of studies have tried to uncover a genetic predisposition for sudden infant death syndrome (SIDS), but there is still uncertainty concerning the pathogenesis of these deaths. The purpose of this study was to investigate mRNA gene expression in SIDS cases and controls, in order to uncover genes that are differentially expressed in the two groups.
methodsTissue from brain, heart, and liver from 15 SIDS cases and 15 controls were included in the study, and mRNA expression was determined using the Illumina whole genome gene expression DASL HT assay.
resultsSeventeen genes showed significantly altered expression compared to controls, after correction for multiple testing. Three genes involved in the immune system were of particular interest, including the downregulation of MyD88 in tissue from SIDS brains, as well as the downregulation of the genes encoding CCL3 and UNC13 in the liver.
conclusionThese findings indicate that there is an altered expression of genes involved in the inflammatory process in a proportion of SIDS cases, which further strengthen the hypothesis that impaired immune response play a role in this syndrome.
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Registered trials
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