ArticleOrganic letters2016
Combinatorial Generation of Chemical Diversity by Redox Enzymes in Chaetoviridin Biosynthesis.
Article in Organic letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Generation of Novel Natural Products by Disrupting Azaphilone Synthesis inMarine drugs · 2026Article
- Polyketide Derivatives from the Macroalga-Associated FungusJournal of natural products · 2025Article
- Advanced Technologies for Large Scale Supply of Marine Drugs.Marine drugs · 2025Review
- Biosynthesis of AS2077715 and Funiculosin: Pathway Reconstitution and Identification of Enzymes that Form the All-Journal of the American Chemical Society · 2023Article
- Naturally Occurring Organohalogen Compounds-A Comprehensive Review.Progress in the chemistry of organic natural products · 2023Review
- Combining OSMAC, metabolomic and genomic methods for the production and annotation of halogenated azaphilones and ilicicolins in termite symbiotic fungi.Scientific reports · 2022Article
- Genome-Based Analysis ofBiology · 2022Article
- Halogenation in Fungi: What Do We Know and What Remains to Be Discovered?Molecules (Basel, Switzerland) · 2022Review
- Chaetomugilins and Chaetoviridins-Promising Natural Metabolites: Structures, Separation, Characterization, Biosynthesis, Bioactivities, Molecular Docking, and Molecular Dynamics.Journal of fungi (Basel, Switzerland) · 2022Review
- Cytochalasans and azaphilones: suitable chemotaxonomic markers for the Chaetomium species.Applied microbiology and biotechnology · 2021Review
- Chemoenzymatic Total Synthesis of Natural Products.Accounts of chemical research · 2021Review
- Genomics-directed activation of cryptic natural product pathways deciphers codes for biosynthesis and molecular function.Journal of natural medicines · 2021Review
- Genome mining of a fungal endophyte of Taxus yunnanensis (Chinese yew) leads to the discovery of a novel azaphilone polyketide, lijiquinone.Microbial biotechnology · 2020Article
- Nature and nurture: confluence of pathway determinism with metabolic and chemical serendipity diversifies Monascus azaphilone pigments.Natural product reports · 2019Review
- Understanding and Improving the Activity of Flavin-Dependent Halogenases via Random and Targeted Mutagenesis.Annual review of biochemistry · 2018Review
- Chlorinated Azaphilone Pigments with Antimicrobial and Cytotoxic Activities Isolated from the Deep Sea Derived Fungus Chaetomium sp. NA-S01-R1.Marine drugs · 2018Article
- Biocatalytic site- and enantioselective oxidative dearomatization of phenols.Nature chemistry · 2018Article
- RadH: A Versatile Halogenase for Integration into Synthetic Pathways.Angewandte Chemie (International ed. in English) · 2017Article
- Function and Structure of MalA/MalA', Iterative Halogenases for Late-Stage C-H Functionalization of Indole Alkaloids.Journal of the American Chemical Society · 2017Article
- Orange, red, yellow: biosynthesis of azaphilone pigments inChemical science · 2017Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Chaetoviridins constitute a large family of structurally related secondary metabolites isolated from Chaetomium fungi. To elucidate the biosynthesis pathway and understand how the chemical diversity of chaetoviridins is generated, gene deletion and in vitro characterization of the four post-PKS modifications enzymes were undertaken. CazL and CazP were identified to have substrate promiscuity that facilitates the formation of nonchlorinated analogues. In addition, enzymatic oxidation and reduction combined with spontaneous dehydration and lactonization of the intermediates further expand the chemical diversity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.