ArticlePLoS genetics2016
AUXIN RESPONSE FACTOR 2 Intersects Hormonal Signals in the Regulation of Tomato Fruit Ripening.
Article in PLoS genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 177 citations in OpenAlex.
- Transcription factor PpWRKY13 targets a cell wall modification gene in peach to regulate fruit softening.BMC plant biology · 2026Article
- A Noncanonical Auxin-Sensing Mechanism Uncovered by Screening the Auxin Response Factor 3 Interacting Proteins in Tomato.International journal of molecular sciences · 2026Article
- Hormone-centric multi-omics atlas of flower and early fruit development in tomato.Plant communications · 2026Article
- Organ-level gene-regulatory networks inferred from transcriptomic data reveal context-specific regulation and highlight novel regulators of ripening and ABA-mediated responses in tomato.Plant communications · 2025Article
- A feedback loop at the THERMOSENSITIVE PARTHENOCARPY 4 locus controls tomato fruit set under heat stress.Nature communications · 2025Article
- Phosphorylation of the strawberry MADS-box CMB1 regulates ripening via the catabolism of abscisic acid.The New phytologist · 2025Article
- Profiling of Known and Novel microRNAs in an Oleaginous Crop Native to the Amazon Basin, Sacha Inchi (Genes · 2025Article
- A KNOTTED1-LIKE HOMEOBOX PROTEIN1-interacting transcription factor SlGATA6 maintains the auxin-response gradient to inhibit abscission.Science advances · 2025Article
- Auxin response factors: important keys for understanding regulatory mechanisms of fleshy fruit development and ripening.Horticulture research · 2024Article
- Development History, Structure, and Function ofInternational journal of molecular sciences · 2024Review
- Fruit ripening and postharvest changes in very early-harvested tomatoes.Horticulture research · 2024Article
- Transcriptome and weighted gene co-expression network analyses reveal key genes and pathways involved in early fruit ripening in Citrus sinensis.BMC genomics · 2024Article
- Integrative analysis of the methylome and transcriptome of tomato fruit (Horticulture research · 2024Article
- Ethylene promotes fruit ripening initiation by downregulating photosynthesis, enhancing abscisic acid and suppressing jasmonic acid in blueberry (Vaccinium ashei).BMC plant biology · 2024Article
- The YABBY Transcription Factor, SlYABBY2a, Positively Regulates Fruit Septum Development and Ripening in Tomatoes.International journal of molecular sciences · 2024Article
- Transcriptional regulation of tomato fruit ripening.Physiology and molecular biology of plants : an international journal of functional plant biology · 2024Review
- An analysis of lncRNAs related to fiber quality and the discovery of their target genes in a Gossypium hirsutum line with Gossypium mustelinum introgression.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Genome-wide identification of the B3 transcription factor family in pepper (Capsicum annuum) and expression patterns during fruit ripening.Scientific reports · 2024Article
- Recent Advances in Studying the Regulation of Fruit Ripening in Tomato Using Genetic Engineering Approaches.International journal of molecular sciences · 2024Review
- Parthenocarpy inPlants (Basel, Switzerland) · 2023Review
9 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The involvement of ethylene in fruit ripening is well documented, though knowledge regarding the crosstalk between ethylene and other hormones in ripening is lacking. We discovered that AUXIN RESPONSE FACTOR 2A (ARF2A), a recognized auxin signaling component, functions in the control of ripening. ARF2A expression is ripening regulated and reduced in the rin, nor and nr ripening mutants. It is also responsive to exogenous application of ethylene, auxin and abscisic acid (ABA). Over-expressing ARF2A in tomato resulted in blotchy ripening in which certain fruit regions turn red and possess accelerated ripening. ARF2A over-expressing fruit displayed early ethylene emission and ethylene signaling inhibition delayed their ripening phenotype, suggesting ethylene dependency. Both green and red fruit regions showed the induction of ethylene signaling components and master regulators of ripening. Comprehensive hormone profiling revealed that altered ARF2A expression in fruit significantly modified abscisates, cytokinins and salicylic acid while gibberellic acid and auxin metabolites were unaffected. Silencing of ARF2A further validated these observations as reducing ARF2A expression let to retarded fruit ripening, parthenocarpy and a disturbed hormonal profile. Finally, we show that ARF2A both homodimerizes and interacts with the ABA STRESS RIPENING (ASR1) protein, suggesting that ASR1 might be linking ABA and ethylene-dependent ripening. These results revealed that ARF2A interconnects signals of ethylene and additional hormones to co-ordinate the capacity of fruit tissue to initiate the complex ripening process.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.