Observational studyObstetrics and gynecology2016
Ultrasound Measurement of the Fetal Adrenal Gland as a Predictor of Spontaneous Preterm Birth.
Observational study in Obstetrics and gynecology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Adrenal volumes in fetuses delivering prior to 32 weeks' gestation: An MRI pilot study.Acta obstetricia et gynecologica Scandinavica · 2024Article
- Maternal adverse childhood experiences impact fetal adrenal volume in a sex-specific manner.Biology of sex differences · 2023Article
- The importance of fetal adrenal gland volume measurement in successful labor induction with oxytocin.The journal of obstetrics and gynaecology research · 2022Article
- Antenatal diagnosis of chorioamnionitis: A review of the potential role of fetal and placental imaging.Prenatal diagnosis · 2022Review
- Should the interval between doses of antenatal corticosteroids be shortened in certain cases? Factors predicting preterm delivery < 48 h from presentation.Archives of gynecology and obstetrics · 2021Article
- Antenatal Fetal Adrenal Measurements at 22 to 30 Weeks' Gestation, Fetal Growth Restriction, and Perinatal Morbidity.American journal of perinatology · 2021Article
- Longitudinal adrenal gland measurements and growth trajectories as risk markers for late preterm delivery.BMC pregnancy and childbirth · 2020Article
- Normal size of the fetal adrenal gland on prenatal magnetic resonance imaging.Pediatric radiology · 2020Article
- Fetal Adrenal Gland Volume a Novel Predictor of Onset of Labor.Journal of obstetrics and gynaecology of India · 2019Article
- Fetal adrenal gland biometry and cervical elastography as predictors of preterm birth: A comparative study.Ultrasound (Leeds, England) · 2018Article
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Authors and funding
22 authors at 15 institutions in 1 country.
Funding
Abstract
objectiveTo estimate whether ultrasound measurement of the fetal adrenal gland remote from delivery in asymptomatic women can accurately predict spontaneous preterm birth.
methodsWe conducted a prospective multicenter observational nested cohort study of asymptomatic nulliparous women with a singleton pregnancy to study adverse pregnancy outcomes. Between 22 0/7 and 30 6/7 weeks of gestation, credentialed ultrasonographers measured the width (width), length (length), and, when able, depth (depth) of the "fetal zone" of the fetal adrenal gland as well as the width (Width), length (Length), and depth (Depth) of the total gland. We used the ratios of each measurement (width/Width, length/Length, and depth/Depth) to control for variation in adrenal size by gestational age. The accuracy of each ratio measurement in predicting spontaneous preterm birth at less than 37 0/7 weeks of gestation and spontaneous preterm birth at less than 34 0/7 weeks of gestation was assessed by receiver operating characteristic curves using area under the curve.
resultsPregnancy outcomes were available for 1,697 women with one or more fetal adrenal gland measurements. Spontaneous preterm birth at less than 37 0/7 weeks of gestation and spontaneous preterm birth at less than 34 0/7 weeks of gestation occurred in 82 (4.8%) and six women (0.4%), respectively. None of the fetal adrenal gland measurements distinguished spontaneous preterm birth from term birth. The areas under the curve (95% confidence intervals) for spontaneous preterm birth at less than 37 0/7 weeks of gestation were 0.51 (0.45-0.58), 0.50 (0.44-0.56), and 0.52 (0.41-0.63) for width/Width, length/Length, and depth/Depth ratios, respectively. The areas under the curve for spontaneous preterm birth at less than 34 0/7 weeks of gestation were 0.52 (0.25-0.79) and 0.55 (0.31-0.79) for width/Width and length/Length ratios, respectively. Additionally, none of the means of the gland measurements were statistically different between those delivering at term and spontaneous at preterm (P>.05).
conclusionFetal adrenal size, as measured by ultrasonography between 22 0/7 and 30 6/7 weeks of gestation, is not predictive of spontaneous preterm birth in asymptomatic nulliparous women.
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