ArticleCell metabolism2016
A Systems Approach to Reverse Engineer Lifespan Extension by Dietary Restriction.
Article in Cell metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 70 citations in OpenAlex.
- Dietary restriction is evolutionarily conserved on the phenotypic and mechanistic level.EMBO reports · 2026Article
- Suppression rather than activation of the integrated stress response (GCN2-ATF4) pathway extends lifespan in the fly.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Remembrance of things past: Towards a life-course biology of aging.PLoS biology · 2026Article
- Intermittent and periodic fasting: molecular mechanisms, health benefits and research challenges.Frontiers in nutrition · 2026Review
- Pelota-mediated ribosome-associated quality control counteracts aging and age-associated pathologies across species.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Nutrient control of growth and metabolism through mTORC1 regulation of mRNA splicing.Molecular cell · 2024Article
- ECDEP: identifying essential proteins based on evolutionary community discovery and subcellular localization.BMC genomics · 2024Article
- Combinatorial interventions in aging.Nature aging · 2023Review
- Rege-1 promotes C. elegans survival by modulating IIS and TOR pathways.PLoS genetics · 2023Article
- Regulation of TFEB nuclear localization by HSP90AA1 promotes autophagy and longevity.Autophagy · 2023Article
- Endogenous DAF-16 spatiotemporal activity quantitatively predicts lifespan extension induced by dietary restriction.Communications biology · 2023Article
- Stimulation of RAS-dependent ROS signaling extends longevity by modulating a developmental program of global gene expression.Science advances · 2022Article
- The landscape of aging.Science China. Life sciences · 2022Review
- Real age prediction from the transcriptome with RAPToR.Nature methods · 2022Article
- C. elegans monitor energy status via the AMPK pathway to trigger innate immune responses against bacterial pathogens.Communications biology · 2022Article
- The Less We Eat, the Longer We Live: Can Caloric Restriction Help Us Become Centenarians?International journal of molecular sciences · 2022Review
- Ageing induces tissue-specific transcriptomic changes in Caenorhabditis elegans.The EMBO journal · 2022Article
- Gene regulatory network inference in long-livediScience · 2022Article
- Betulinic acid increases lifespan and stress resistanceFrontiers in nutrition · 2022Article
- Evaluating the beneficial effects of dietary restrictions: A framework for precision nutrigeroscience.Cell metabolism · 2021Review
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Dietary restriction (DR) is the most powerful natural means to extend lifespan. Although several genes can mediate responses to alternate DR regimens, no single genetic intervention has recapitulated the full effects of DR, and no unified system is known for different DR regimens. Here we obtain temporally resolved transcriptomes during calorie restriction and intermittent fasting in Caenorhabditis elegans and find that early and late responses involve metabolism and cell cycle/DNA damage, respectively. We uncover three network modules of DR regulators by their target specificity. By genetic manipulations of nodes representing discrete modules, we induce transcriptomes that progressively resemble DR as multiple nodes are perturbed. Targeting all three nodes simultaneously results in extremely long-lived animals that are refractory to DR. These results and dynamic simulations demonstrate that extensive feedback controls among regulators may be leveraged to drive the regulatory circuitry to a younger steady state, recapitulating the full effect of DR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.