Evidence map›Paper›PMID 26959071›Full record

ArticleJournal of functional biomaterials2016

Fabrication of Gelatin/PCL Electrospun Fiber Mat with Bone Powder and the Study of Its Biocompatibility.

Dongming Rong, Ping Chen, Yuchao Yang, Qingtao Li, Wenbing Wan, Xingxing Fang, Jie Zhang, Zhongyu Han, Jing Tian, Jun Ouyang

Open access · goldAbstract read
In one paragraph

Article in Journal of functional biomaterials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Dongming RongDepartment of Orthopaedic, Zhujiang Hospital, Southern Medical University, No. 253, Gongye Avenue, Haizhu District, Guangzhou 510280, Guangdong, China. rong_dm1989@163.com.
Ping ChenDepartment of Orthopaedic, Zhujiang Hospital, Southern Medical University, No. 253, Gongye Avenue, Haizhu District, Guangzhou 510280, Guangdong, China. cp19900717@163.com.
Yuchao YangDepartment of Anatomy, Guangdong Provincial Medical Biomechanical Key Laboratory, Southern Medical University, Baiyun District, Guangzhou 510515, Guangdong, China. gzyyc27@126.com.
Qingtao LiDepartment of Anatomy, Guangdong Provincial Medical Biomechanical Key Laboratory, Southern Medical University, Baiyun District, Guangzhou 510515, Guangdong, China. mcqtli@scut.edu.cn.
Wenbing WanDepartment of Anatomy, Guangdong Provincial Medical Biomechanical Key Laboratory, Southern Medical University, Baiyun District, Guangzhou 510515, Guangdong, China. zwwb214@163.com.
Xingxing FangDepartment of Anatomy, Guangdong Provincial Medical Biomechanical Key Laboratory, Southern Medical University, Baiyun District, Guangzhou 510515, Guangdong, China. Doc_Fang688@126.com.
Jie ZhangDepartment of Orthopaedic, Zhujiang Hospital, Southern Medical University, No. 253, Gongye Avenue, Haizhu District, Guangzhou 510280, Guangdong, China. kamizj891026@126.com.
Zhongyu HanDepartment of Orthopaedic, Zhujiang Hospital, Southern Medical University, No. 253, Gongye Avenue, Haizhu District, Guangzhou 510280, Guangdong, China. hanzhongyu901001@aliyun.com.
Jing TianDepartment of Orthopaedic, Zhujiang Hospital, Southern Medical University, No. 253, Gongye Avenue, Haizhu District, Guangzhou 510280, Guangdong, China. tianjing_ortho@163.com.
Jun OuyangDepartment of Anatomy, Guangdong Provincial Medical Biomechanical Key Laboratory, Southern Medical University, Baiyun District, Guangzhou 510515, Guangdong, China. jouyang@smu.edu.cn.
Southern Medical University · CNZhujiang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fabricating ideal scaffolds for bone tissue engineering is a great challenge to researchers. To better mimic the mineral component and the microstructure of natural bone, several kinds of materials were adopted in our study, namely gelatin, polycaprolactone (PCL), nanohydroxyapatite (nHA), and bone powder. Three types of scaffolds were fabricated using electrospinning; gelatin/PCL, gelatin/PCL/nHA, and gelatin/PCL/bone powder. Scaffolds were examined using scanning electron microscopy (SEM) and transmission electron microscopy (TEM) observations. Then, Adipose-derived Stem Cells (ADSCs) were seeded on these scaffolds to study cell morphology, cell viability, and proliferation. Through this study, we found that nHA and bone powder can be successfully united in gelatin/PCL fibers. When compared with gelatin/PCL and gelatin/PCL/nHA, the gelatin/PCL/bone powder scaffolds could provide a better environment to increase ADSCs' growth, adhesion, and proliferation. Thus, we think that gelatin/PCL/bone powder has good biocompatibility, and, when compared with nHA, bone powder may be more effective in bone tissue engineering due to the bioactive factors contained in it.

Indexed as

bone tissue engineeringelectrospinninggelatinpolycaprolactonescaffold

Identifiers

PMID26959071
PMCPMC4810065
OpenAlexW2289958234

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.