ArticleOncotarget2016
An image guided small animal stereotactic radiotherapy system.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Characterization of a commercial bioluminescence tomography-guided system for pre-clinical radiation research.Medical physics · 2023Article
- Radiation nephropathy: Mechanisms of injury and recovery in a murine model.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2023Article
- Article
- Mobile bioluminescence tomography-guided system for pre-clinical radiotherapy research.Biomedical optics express · 2022Article
- Quantitative Bioluminescence Tomography-Guided Conformal Irradiation for Preclinical Radiation Research.International journal of radiation oncology, biology, physics · 2021Article
- Noninvasive assessment of radiation-induced renal injury in mice.International journal of radiation biology · 2021Article
- Modulation of radiation-induced damage of human glomerular endothelial cells by SMPDL3B.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Review
- Integrating Small Animal Irradiators withFunctional Imaging for Advanced Preclinical Radiotherapy Research.Cancers · 2019Review
- The Path Toward PET-Guided Radiation Therapy for Glioblastoma in Laboratory Animals: A Mini Review.Frontiers in medicine · 2019Review
- Plasmonic Optical Imaging of Gold Nanorods Localization in Small Animals.Scientific reports · 2018Article
- Sphingomyelinase-like phosphodiesterase 3b mediates radiation-induced damage of renal podocytes.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Differentiation and Localization of Adjacent Murine Tumors Using X-ray and Bioluminescence Tomography.Technology in cancer research & treatmentArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small animal radiotherapy studies should be performed preferably on irradiators capable of focal tumor irradiation and healthy tissue sparing. In this study, an image guided small animal arc radiation treatment system (iSMAART) was developed which can achieve highly precise radiation targeting through the utilization of onboard cone beam computed tomography (CBCT) guidance. The iSMAART employs a unique imaging and radiation geometry where animals are positioned upright. It consists of a stationary x-ray tube, a stationary flat panel detector, and a rotatable and translational animal stage. System performance was evaluated in regards to imaging, image guidance, animal positioning, and radiation targeting using phantoms and tumor bearing animals. The onboard CBCT achieved good signal, contrast, and sub-millimeter spatial resolution. The iodine contrast CBCT accurately delineated orthotopic prostate tumors. Animal positioning was evaluated with ~0.3 mm vertical displacement along superior-inferior direction. The overall targeting precision was within 0.4 mm. Stereotactic radiation beams conformal to tumor targets can be precisely delivered from multiple angles surrounding the animal. The iSMAART allows radiobiology labs to utilize an image guided precision radiation technique that can focally irradiate tumors while sparing healthy tissues at an affordable cost.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.