Evidence map›Paper›PMID 26958924›Full record

ReviewAnnual review of virology2015

Everything You Always Wanted to Know About Rabies Virus (But Were Afraid to Ask).

Benjamin M Davis, Glenn F Rall, Matthias J Schnell

Abstract readReview
In one paragraph

Review in Annual review of virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 176 citations in OpenAlex.

  1. Trial
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  11. A SynB1-conjugated antibody cocktail crosses the blood-brain barrier to produce a therapeutic effect on rabies.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Tetanus: recognition and management.The Lancet. Infectious diseases · 2025
    Review
  14. Article
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34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Benjamin M DavisDepartment of Microbiology and Immunology and.
Glenn F RallFox Chase Cancer Center, Philadelphia, Pennsylvania 19111.
Matthias J SchnellDepartment of Microbiology and Immunology and.
Fox Chase Cancer Center · USThomas Jefferson University · US

Funding

CENTER FOR NEUROANATOMY WITH NEUROTROPIC VIRUSES: COMPARATIVE MEDICINEP40RR018604 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STRICK, PETER · 2004 to 2011
$6.5M
Preclinical characterization of a multivalent killed Filovirus/Rabies vaccineR01AI105204 · NIAID · THOMAS JEFFERSON UNIVERSITY · PI SCHNELL, MATTHIAS JOHANNES · 2013 to 2017
$5.0M
A novel vaccine: botulinum neurotoxin subunit on a viral carrier.R42AI073064 · NIAID · MOLECULAR TARGETING TECHNOLOGIES, INC. · PI SCHNELL, MATTHIAS JOHANNES · 2012 to 2014
$2.5M
Fate of neurons following immune-mediated viral clearanceR21NS074006 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI RALL, GLENN F, SCHNELL, MATTHIAS JOHANNES · 2011 to 2012
$467k
NCRR NIH HHS P40 RR018604NCRR NIH HHS P40RR018604NIAID NIH HHS R01 AI105204NIAID NIH HHS R01AI105204,NIAID NIH HHS R42 AI073064NIAID NIH HHS R42AI073064NINDS NIH HHS R21 NS074006NINDS NIH HHS R21NS074006
6 · The paper itself

Abstract

The cultural impact of rabies, the fatal neurological disease caused by infection with rabies virus, registers throughout recorded history. Although rabies has been the subject of large-scale public health interventions, chiefly through vaccination efforts, the disease continues to take the lives of about 40,000-70,000 people per year, roughly 40% of whom are children. Most of these deaths occur in resource-poor countries, where lack of infrastructure prevents timely reporting and postexposure prophylaxis and the ubiquity of domestic and wild animal hosts makes eradication unlikely. Moreover, although the disease is rarer than other human infections such as influenza, the prognosis following a bite from a rabid animal is poor: There is currently no effective treatment that will save the life of a symptomatic rabies patient. This review focuses on the major unanswered research questions related to rabies virus pathogenesis, especially those connecting the disease progression of rabies with the complex dysfunction caused by the virus in infected cells. The recent applications of cutting-edge research strategies to this question are described in detail.

Indexed as

AnimalsHumansKnowledgeRabiesRabies virusVirulencelyssavirusesneuroinvasive virusneurotropic virusrabies virusviral transport

Identifiers

PMID26958924
PMCPMC6842493
OpenAlexW2157556858

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.