Evidence map›Paper›PMID 26958921›Full record

ReviewAnnual review of virology2015

Virus-Based Nanoparticles as Versatile Nanomachines.

Kristopher J Koudelka, Andrzej S Pitek, Marianne Manchester, Nicole F Steinmetz

Abstract readReview
In one paragraph

Review in Annual review of virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Isopeptide BondingViruses · 2023
    Article
  11. Review
  12. Review
  13. Construction of HER2-Specific HIV-1-Based VLPs.Bioengineering (Basel, Switzerland) · 2022
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kristopher J KoudelkaDepartment of Biology, Point Loma Nazarene University, San Diego, California 92106; email: kkoudelk@pointloma.edu.
Andrzej S PitekDepartments of 2Biomedical Engineering.
Marianne ManchesterSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093.
Nicole F SteinmetzDepartments of 2Biomedical Engineering.

Funding

Drug Delivery to Thrombotic Cardiovascular DiseaseR21HL121130 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI STEINMETZ, NICOLE FRANZISKA · 2015 to 2016
$416k
NHLBI NIH HHS R21 HL121130
6 · The paper itself

Abstract

Nanoscale engineering is revolutionizing the way we prevent, detect, and treat diseases. Viruses have played a special role in these developments because they can function as prefabricated nanoscaffolds that have unique properties and are easily modified. The interiors of virus particles can encapsulate and protect sensitive compounds, while the exteriors can be altered to display large and small molecules in precisely defined arrays. These properties of viruses, along with their innate biocompatibility, have led to their development as actively targeted drug delivery systems that expand on and improve current pharmaceutical options. Viruses are naturally immunogenic, and antigens displayed on their surface have been used to create vaccines against pathogens and to break self-tolerance to initiate an immune response to dysfunctional proteins. Densely and specifically aligned imaging agents on viruses have allowed for high-resolution and noninvasive visualization tools to detect and treat diseases earlier than previously possible. These and future applications of viruses have created an exciting new field within the disciplines of both nanotechnology and medicine.

Indexed as

AnimalsDrug Delivery SystemsHumansNanoparticlesNanotechnologyVirusesdrug deliveryimagingnanotechnologyvaccinesviruses

Identifiers

PMID26958921
PMCPMC5177684

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.