ReviewAnnual review of virology2015
Hunting Viral Receptors Using Haploid Cells.
Review in Annual review of virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Dissecting host-microbe interactions with modern functional genomics.Current opinion in microbiology · 2024Review
- Review
- Characterizing Marine Medaka (Animals : an open access journal from MDPI · 2024Article
- Significance of Artificial Intelligence in the Study of Virus-Host Cell Interactions.Biomolecules · 2024Review
- The many ways in which alphaviruses bind to cells.Trends in immunology · 2024Review
- Entry receptors - the gateway to alphavirus infection.The Journal of clinical investigation · 2023Review
- Replicating-Competent VSV-Vectored Pseudotyped Viruses.Advances in experimental medicine and biology · 2023Article
- GPI-anchored ligand-BioID2-tagging system identifies Galectin-1 mediating Zika virus entry.iScience · 2022Article
- Stress Decreases Host Viral Resistance and Increases Covid Susceptibility in Embryonic Stem Cells.Stem cell reviews and reports · 2021Article
- CRISPR Tackles Emerging Viral Pathogens.Viruses · 2021Review
- Recent Advances in Bunyavirus Glycoprotein Research: Precursor Processing, Receptor Binding and Structure.Viruses · 2021Review
- Review
- E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Advances in high-throughput methods for the identification of virus receptors.Medical microbiology and immunology · 2020Review
- Article
- Glycomics and Proteomics Approaches to Investigate Early Adenovirus-Host Cell Interactions.Journal of molecular biology · 2018Review
- Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis.Arteriosclerosis, thrombosis, and vascular biology · 2017Article
- Diverse Viruses Require the Calcium Transporter SPCA1 for Maturation and Spread.Cell host & microbe · 2017Article
- A CRISPR toolbox to study virus-host interactions.Nature reviews. Microbiology · 2017Review
- Host determinants of adeno-associated viral vector entry.Current opinion in virology · 2017Review
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Viruses have evolved intricate mechanisms to gain entry into the host cell. Identification of host proteins that serve as viral receptors has enabled insights into virus particle internalization, host and tissue tropism, and viral pathogenesis. In this review we discuss the most commonly employed methods for virus receptor discovery, specifically highlighting the use of forward genetic screens in human haploid cells. The ability to generate true knockout alleles at high saturation provides a sensitive means to study virus-host interactions. To illustrate the power of such haploid genetic screens, we highlight the discovery of the lysosomal proteins NPC1 and LAMP1 as intracellular receptors for Ebola virus and Lassa virus, respectively. From these studies emerges the notion that receptor usage by these viruses is highly dynamic, involving a programmed switch from cell surface receptor to intracellular receptor. Broad application of genetic knockout approaches will chart functional landscapes of receptors and endocytic pathways hijacked by viruses.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.