Observational studyCritical care medicine2016
Admission Hyperglycemia in Critically Ill Sepsis Patients: Association With Outcome and Host Response.
Observational study in Critical care medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03617965 (Mortality Due to Septic Shock Associated With Thrombocytopenia in the Intensive Care Unit), which is not on this map. Cited by 70 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mortality Due to Septic Shock Associated With Thrombocytopenia in the Intensive Care Unit
Who cites it
70 citing papers in PubMed, 2 syntheses or guidelines pooled it, 130 citations in OpenAlex.
- Stress-induced hyperglycemia and mortality of non-diabetic patients with sepsis: a meta-analysis.Frontiers in endocrinology · 2025Pooled it
- American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022Guideline
- A digital twin for tracking and forecasting glycemia with septic patients in ICUs.npj metabolic health and disease · 2026Article
- Blood Glucose Trajectories and Mortality in Sepsis-Induced Coagulopathy: A Latent Growth Mixture Modeling Analysis.Shock (Augusta, Ga.) · 2026Article
- Cardiovascular-Kidney-Metabolic (CKM) Syndrome as Independent Risk Factor for Pneumococcal Pneumonia: Evidence from a Territory-Wide Study.Microorganisms · 2026Article
- Continuous vs. intermittent infusion of corticosteroids in septic shock: a GRADE-based systematic review and meta-analysis.Journal of anesthesia, analgesia and critical care · 2026Review
- Machine learning glucose forecasting models for septic patients.Scientific reports · 2025Article
- Beyond diabetes: harnessing the power of metformin in burn care.Critical care (London, England) · 2025Review
- Correlation between stress hyperglycemia ratio and risk of acute respiratory distress syndrome in patients with sepsis: a MIMIC-IV cohort study.Scientific reports · 2025Article
- Implementation of an Evidence-Based Protocol for Blood Glucose Management in Critically Ill Adult Patients: A Pilot Study.Nursing in critical care · 2025Article
- Stress hyperglycemia ratio as a mortality predictor in non-diabetic septic patients: a retrospective cohort analysis.BMC infectious diseases · 2025Article
- The Association Between Dysglycemia and Endotheliopathy in ICU Patients With and Without Diabetes: A Cohort Study.Critical care explorations · 2025Observational
- The Impact of SARS-CoV-2 Infection on Glucose Homeostasis in Hospitalized Patients with Pulmonary Impairment.Diagnostics (Basel, Switzerland) · 2025Article
- Association between various blood glucose variability-related indicators during early ICU admission and 28-day mortality in non-diabetic patients with sepsis.Diabetology & metabolic syndrome · 2025Article
- Development and Validation of a Dynamic Nomogram for Sepsis-Associated Encephalopathy in Elderly ICU Patients with Sepsis: A Retrospective Cohort Study.International journal of general medicine · 2025Article
- Bacteremia detected on peripheral blood smear in small animal patients presenting to the Emergency Department and its association with prognosis to discharge.Frontiers in veterinary science · 2025Article
- Development and validation of an ensemble learning risk model for sepsis after abdominal surgery.Archives of medical science : AMS · 2025Article
- Incidence and outcomes of early hyperglycaemia in critically ill patients.The Southern African journal of critical care : the official journal of the Critical Care Society · 2025Article
- Acute Coronary Syndrome After Aneurysmal Subarachnoid Hemorrhage: Incidence, Risk Factors and Impact on the Outcome.Medicina (Kaunas, Lithuania) · 2024Article
- High sugar diets can increase susceptibility to bacterial infection in Drosophila melanogaster.PLoS pathogens · 2024Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate whether admission hyperglycemia is associated with the presentation and/or outcome of sepsis, what the influence of hyperglycemia is on key host responses to sepsis, and whether hyperglycemia differentially affects patients with diabetes mellitus. DESIGN AND
settingA substudy of a prospective observational cohort study was conducted in the intensive care of two tertiary hospitals between January 2011 and July 2013. PATIENTS: Of all consecutive critically ill sepsis patients, admission glucose was used to stratify patients in euglycemia (71-140 mg/dL), mild hyperglycemia (141-199 mg/dL), and severe hyperglycemia (≥ 200 mg/dL), and patients with hypoglycemia were excluded. Fifteen plasma biomarkers providing insight in key host responses implicated in sepsis pathogenesis were measured on admission. MEASUREMENTS AND MAIN
resultsOf 987 sepsis patients with admission glucose levels greater than 70 mg/dL, 519 (52.6%) had normal glucose levels, 267 (27.1%) had mild, and 201 (20.4%) severe hyperglycemia. Admission hyperglycemia was accompanied by mitigated alterations in plasma host response biomarker levels indicative of activation of the cytokine network, the vascular endothelium, and the coagulation system in patients without a history of diabetes. Severe, but not mild, admission hyperglycemia was associated with increased 30-day mortality (adjusted hazard ratio, 1.66 [95% CI, 1.24-2.23]), in both patients without diabetes (adjusted hazard ratio, 1.65 [95% CI, 1.12-2.42]) and with diabetes (adjusted hazard ratio, 1.91 [95% CI, 1.01-3.62]).
conclusionAdmission hyperglycemia is associated with adverse outcome of sepsis irrespective of the presence or absence of preexisting diabetes by a mechanism unrelated to exaggerated inflammation or coagulation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.