Evidence map›Paper›PMID 26958643›Full record

ArticleData in brief2016

Detailed analysis of association between common single nucleotide polymorphisms and subclinical atherosclerosis: The Multi-ethnic Study of Atherosclerosis.

Jose D Vargas, Ani Manichaikul, Xin-Qun Wang, Stephen S Rich, Jerome I Rotter, Wendy S Post, Joseph F Polak, Matthew J Budoff, David A Bluemke

Open access · goldAbstract read
In one paragraph

Article in Data in brief, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Association ofJournal of cardiovascular development and disease · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Disease-Associated Risk Variants inCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Article
  8. Article
  9. Article
  10. Article
  11. Association between theNutrition & metabolism · 2018
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Jose D VargasMedStar Health Research Institute, Georgetown University Hospital, Washington, District of Columbia, USA; National Institutes of Health, Radiology and Imaging Sciences, Bethesda, MD, USA.
Ani ManichaikulBiostatistics Section, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA; Center for Public Health and Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Xin-Qun WangBiostatistics Section, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Stephen S RichCenter for Public Health and Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Jerome I RotterLos Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Institute for Translational Genomics and Population Sciences, Torrance, CA, USA.
Wendy S PostDivision of Cardiology, Johns Hopkins University, Baltimore, MD, USA.
Joseph F PolakDepartment of Radiology, Tufts University School of Medicine, Boston, MA, USA.
Matthew J BudoffLos Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, USA.
David A BluemkeNational Institutes of Health, Radiology and Imaging Sciences, Bethesda, MD, USA.
University of Virginia · USNational Institutes of Health Clinical Center · USHarbor–UCLA Medical Center · USJohns Hopkins University · USTufts University · USUCLA Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previously identified single nucleotide polymorphisms (SNPs) in genome wide association studies (GWAS) of cardiovascular disease (CVD) in participants of mostly European descent were tested for association with subclinical cardiovascular disease (sCVD), coronary artery calcium score (CAC) and carotid intima media thickness (CIMT) in the Multi-Ethnic Study of Atherosclerosis (MESA). The data in this data in brief article correspond to the article Common Genetic Variants and Subclinical Atherosclerosis: The Multi-Ethnic Study of Atherosclerosis [1]. This article includes the demographic information of the participants analyzed in the article as well as graphical displays and data tables of the association of the selected SNPs with CAC and of the meta-analysis across ethnicities of the association of CIMT-c (common carotid), CIMT-I (internal carotid), CAC-d (CAC as dichotomous variable with CAC>0) and CAC-c (CAC as continuous variable, the log of the raw CAC score plus one) and CVD. The data tables corresponding to the 9p21 fine mapping experiment as well as the power calculations referenced in the article are also included.

Indexed as

Carotid intima-media thickness (CIMT)Common genetic variantCoronary artery calcium (CAC)Single nucleotide polymorphism (SNP)Subclincal atherosclerosis

Identifiers

PMID26958643
PMCPMC4773483
OpenAlexW2278681919

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.