Evidence map›Paper›PMID 26958631›Full record

ArticleData in brief2016

Liver metal levels and expression of genes related to iron homeostasis in rhesus monkeys after inhalational manganese exposure.

Michael A Pettiglio, Carolina Herrera, Melanie L Foster, David C Dorman, Thomas B Bartnikas

Open access · goldAbstract read
In one paragraph

Article in Data in brief, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Michael A PettiglioBrown University, Department of Pathology and Laboratory Medicine, 70 Ship St., Rm. 522, Providence, RI 02912, USA.
Carolina HerreraBrown University, Department of Pathology and Laboratory Medicine, 70 Ship St., Rm. 522, Providence, RI 02912, USA.
Melanie L FosterNorth Carolina State University, College of Veterinary Medicine, 1060 William Moore Drive, Raleigh, NC 27607, USA.
David C DormanNorth Carolina State University, College of Veterinary Medicine, 1060 William Moore Drive, Raleigh, NC 27607, USA.
Thomas B BartnikasBrown University, Department of Pathology and Laboratory Medicine, 70 Ship St., Rm. 522, Providence, RI 02912, USA.
Brown University · USNorth Carolina State University · US

Funding

Molecular Basis of Mammalian Manganese HomeostasisR01DK110049 · NIDDK · BROWN UNIVERSITY · PI BARTNIKAS, THOMAS BENEDICT · 2016 to 2025
$3.6M
Regulation of mammalian iron homeostasis by iron and transferrinR00DK084122 · NIDDK · BROWN UNIVERSITY · PI BARTNIKAS, THOMAS BENEDICT · 2013 to 2015
$722k
NIDDK NIH HHS R00 DK084122
6 · The paper itself

Abstract

Here we present data on liver metal levels and expression of genes related to iron homeostasis in rhesus monkeys after inhalational manganese exposure. Archived liver samples from rhesus monkeys exposed to 0 (n=6), 0.06 (n=6), 0.3 (n=4) and 1.5 (n=4) mg/m(3) manganese inhalation for 65 days were obtained from a published study ("Tissue manganese concentrations in young male rhesus monkeys following subchronic manganese sulfate inhalation" [1]). Samples were analyzed by spectroscopy, immunoblotting and quantitative PCR to assess metal levels and gene expression. Liver manganese and iron levels were linearly correlated although only the intermediate manganese exposure level (0.3 mg Mn/m(3)) led to a statistically significant increase in liver iron levels.

Indexed as

InhalationIronManganeseMonkey

Identifiers

PMID26958631
PMCPMC4763106
OpenAlexW2260750285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.