ArticleClinical psychological science : a journal of the Association for Psychological Science2016
Interaction of CD38 Variant and Chronic Interpersonal Stress Prospectively Predicts Social Anxiety and Depression Symptoms Over Six Years.
Article in Clinical psychological science : a journal of the Association for Psychological Science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Oxytocin, but not vasopressin, impairs social cognitive ability among individuals with higher levels of social anxiety: a randomized controlled trial.Social cognitive and affective neuroscience · 2016Trial
- CD38 connects the heart and brain.Translational psychiatry · 2025Review
- CD38 genetic variation is associated with increased personal distress to an emotional stimulus.Scientific reports · 2024Article
- CD38 is associated with bonding-relevant cognitions and relationship satisfaction over the first 3 years of marriage.Scientific reports · 2021Observational
- Predictors of social anxiety disorder with major depressive episodes among Japanese university students.PloS one · 2021Article
- Oxytocin Pathway Gene (Frontiers in psychiatry · 2021Article
- CD38 is associated with communal behavior, partner perceptions, affect and relationship adjustment in romantic relationships.Scientific reports · 2020Article
- Cumulative Risk on Oxytocin-Pathway Genes Impairs Default Mode Network Connectivity in Trauma-Exposed Youth.Frontiers in endocrinology · 2020Article
- Preliminary Evidence That CD38 Moderates the Association of Neuroticism on Amygdala-Subgenual Cingulate Connectivity.Frontiers in neuroscience · 2020Article
- The cortisol awakening response (CAR) interacts with acute interpersonal stress to prospectively predict depressive symptoms among early adolescent girls.Psychoneuroendocrinology · 2019Article
- Gene-Environment Interactions in Psychiatry: Recent Evidence and Clinical Implications.Current psychiatry reports · 2019Review
- FoxO1, A2M, and TGF-β1: three novel genes predicting depression in gene X environment interactions are identified using cross-species and cross-tissues transcriptomic and miRNomic analyses.Molecular psychiatry · 2018Article
- Article
- Oxytocin and Anxiety Disorders: Translational and Therapeutic Aspects.Current psychiatry reports · 2017Review
- Time-varying and time-invariant dimensions of depression in children and adolescents: Implications for cross-informant agreement.Journal of abnormal psychology · 2017Article
- Oxytocin and Social Sensitivity: Gene Polymorphisms in Relation to Depressive Symptoms and Suicidal Ideation.Frontiers in human neuroscience · 2016Article
- Chronic and episodic interpersonal stress as statistically unique predictors of depression in two samples of emerging adults.Journal of abnormal psychology · 2015Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Variation in the CD38 gene, which regulates secretion of the neuropeptide oxytocin, has been associated with several social phenotypes. Specifically, rs3796863 A allele carriers have demonstrated increased social sensitivity. In 400 older adolescents, we used trait-state-occasion modeling to investigate how rs3796863 genotype, baseline ratings of chronic interpersonal stress, and their gene-environment (GxE) interaction predicted trait social anxiety and depression symptoms over six years. We found significant GxE effects for CD38 A-carrier genotypes and chronic interpersonal stress at baseline predicting greater social anxiety and depression symptoms. A significant GxE effect of smaller magnitude was also found for C/C genotype and chronic interpersonal stress predicting greater depression; however, this effect was small compared to the main effect of chronic interpersonal stress. Thus, in the context of chronic interpersonal stress, heightened social sensitivity associated with the rs3796863 A allele may prospectively predict risk for social anxiety and (to a lesser extent) depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.