Evidence map›Paper›PMID 26958204›Full record

ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2015

Initial Readability Assessment of Clinical Trial Eligibility Criteria.

Tian Kang, Noémie Elhadad, Chunhua Weng

Abstract read
In one paragraph

Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Text Classification of Cancer Clinical Trial Eligibility Criteria.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2023
    Article
  3. Article
  4. The My Cancer Genome clinical trial data model and trial curation workflow.Journal of the American Medical Informatics Association : JAMIA · 2020
    Article
  5. EliIE: An open-source information extraction system for clinical trial eligibility criteria.Journal of the American Medical Informatics Association : JAMIA · 2017
    Article
  6. Article
  7. Article
  8. Readability of Cancer Clinical Trials Websites.Cancer control : journal of the Moffitt Cancer Center
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tian KangDepartment of Biomedical Informatics, Columbia University, New York, NY 10032.
Noémie ElhadadDepartment of Biomedical Informatics, Columbia University, New York, NY 10032.
Chunhua WengDepartment of Biomedical Informatics, Columbia University, New York, NY 10032.

Funding

Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Bridging the Semantic Gap Between Research Eligibility Criteria and Clinical DataR01LM009886 · NLM · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WENG, CHUNHUA · 2009 to 2020
$5.3M
NCATS NIH HHS UL1 TR000040NLM NIH HHS R01 LM009886
6 · The paper itself

Abstract

Various search engines are available to clinical trial seekers. However, it remains unknown how comprehensible clinical trial eligibility criteria used for recruitment are to a lay audience. This study initially investigated this problem. Readability of eligibility criteria was assessed according to (i) shallow and lexical characteristics through the use of an established, generic readability metric; (ii) syntactic characteristics through natural language processing techniques; and (iii) health terminological characteristics through an automated comparison to technical and lay health texts. We further stratified clinical trials according to various study characteristics (e.g., source country or study type) to understand potential factors influencing readability. Mainly caused by frequent use of technical jargons, a college reading level was found to be necessary to understand eligibility criteria text, a level much higher than the average literacy level of the general American population. The use of technical jargons should be minimized to simplify eligibility criteria text.

Indexed as

Clinical Trials as TopicComprehensionEligibility DeterminationHumansNatural Language ProcessingReadingSearch Engine

Identifiers

PMID26958204
PMCPMC4765646

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.