ArticleKorean journal of pediatrics2016
Epilepsy in children with a history of febrile seizures.
Article in Korean journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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15 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- The baseline risk of multiple febrile seizures in the same febrile illness: a meta-analysis.European journal of pediatrics · 2022Pooled it
- Optimized Preparation ofCurrent issues in molecular biology · 2026Article
- Incidence and clinical predictors of epilepsy after febrile seizures in children: A prospective cohort study in Vietnam.Epilepsia open · 2026Article
- The genotypic spectrum of complex febrile seizures: insights from high-risk population genetic screening in a pediatric cohort.Frontiers in neuroscience · 2026Article
- Article
- Genome-Wide Association Study Identifying a Novel Gene Related to a History of Febrile Convulsions in Patients With Focal Epilepsy.Journal of clinical neurology (Seoul, Korea) · 2025Article
- 7p22.3 microdeletion: a case study of a patient with congenital heart defect, neurodevelopmental delay and epilepsy.Orphanet journal of rare diseases · 2024Article
- Determinants of epilepsy among outpatients in public health institutions of Dawo district, South West Shoa Zone, Oromia, Ethiopia, 2023: an institutional-based unmatched case-control study.Frontiers in neurology · 2024Article
- Exploring the Age-Old Question: What Is the Predictive Value of EEG for Future Epilepsy in Children With Complex Febrile Seizures?Journal of child neurology · 2023Article
- Pathogenetic and etiologic considerations of febrile seizures.Clinical and experimental pediatrics · 2023Article
- Evaluation of the risk factors for recurrence and the development of epilepsy in patients with febrile seizure.Arquivos de neuro-psiquiatria · 2022Article
- Experimental Therapeutic Strategies in Epilepsies Using Anti-Seizure Medications.Journal of experimental pharmacology · 2021Review
- Anthropogenetic Variability in the Group of Individuals with Febrile Seizures: Population-Genetic Study.BioMed research international · 2018Article
- Febrile seizures: an overview.Drugs in context · 2018Review
- Prognostic factors for epilepsy following first febrile seizure in Saudi children.Annals of Saudi medicineArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeFebrile seizure, the most common type of pediatric convulsive disorder, is a benign seizure syndrome distinct from epilepsy. However, as epilepsy is also common during childhood, we aimed to identify the prognostic factors that can predict epilepsy in children with febrile seizures.
methodsThe study comprised 249 children at the Korea University Ansan Hospital who presented with febrile seizures. The relationship between the subsequent occurrence of epilepsy and clinical factors including seizure and fever-related variables were analyzed by multivariate analysis.
resultsTwenty-five patients (10.0%) had additional afebrile seizures later and were diagnosed with epilepsy. The subsequent occurrence of epilepsy in patients with a history of febrile seizures was associated with a seizure frequency of more than 10 times during the first 2 years after seizure onset (P<0.001). Factors that were associated with subsequent occurrence of epilepsy were developmental delay (P<0.001), preterm birth (P=0.001), multiple seizures during a febrile seizure attack (P=0.005), and epileptiform discharges on electroencephalography (EEG) (P=0.008). Other factors such as the age at onset of first seizure, seizure duration, and family history of epilepsy were not associated with subsequent occurrence of epilepsy in this study.
conclusionFebrile seizures are common and mostly benign. However, careful observation is needed, particularly for prediction of subsequent epileptic episodes in patients with frequent febrile seizures with known risk factors, such as developmental delay, history of preterm birth, several attacks during a febrile episode, and epileptiform discharges on EEG.
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