ArticleAfrican health sciences2015
Clinical and genetic data of Huntington disease in Moroccan patients.
Article in African health sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Variation in the reported prevalence of Huntington's disease: a systematic review and guide to interpretation.Journal of neurology · 2025Pooled it
- Biological sex differences in neurodegenerative diseases in Africa: a scoping review of evidence and research gaps.BMC neurology · 2026Article
- An exploration of the genetics of the mutant Huntingtin (mHtt) gene in a cohort of patients with chorea from different ethnic groups in sub-Saharan Africa.Annals of human genetics · 2025Article
- Biomarkers of neurodegeneration across the Global South.The lancet. Healthy longevity · 2024Review
- Dementia in Africa: Current evidence, knowledge gaps, and future directions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Review
- From sexual orientation to cochlear transplants in a tropical environment.African health sciences · 2015Article
- "Clinical Profile of Genetically Proven Huntington's Disease Patients from Eastern India".Annals of Indian Academy of NeurologyArticle
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuntington's disease (HD) occurs worldwide with prevalence varying from 0.1 to 10/100,000 depending of the ethnic origin. Since no data is available in the Maghreb population, the aim of this study is to describe clinical and genetic characteristics of Huntington patients of Moroccan origin.
methodsClinical and genetics data of 21 consecutive patients recruited from 2009 to 2014 from the outpatient clinic of six medical centers were analyzed. Statistical analysis was performed using descriptive statistics.
resultsTwenty one patients from 17 families were diagnosed positive for the IT15 gene CAG expansion. Clinical symptoms were predominantly motor (19/21). Twelve patients had psychiatric and behavioral disorders, and 11 patients had cognitive disorders essentially of memory impairment. Analysis of genetic results showed that 5 patients had reduced penetrant (RP) alleles and 16 had fully penetrant (FP) alleles. The mean CAG repeat length in patients with RP alleles was 38.4 ± 0.54, and 45.37 ± 8.30 in FP alleles. The age of onset and the size of the CAG repeat length showed significant inverse correlation (p <0.001, r = -0.754).
conclusionClinical and genetic data of Moroccan patients are similar to those of Caucasian populations previously reported in the literature.
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