ArticleAfrican health sciences2015
Polymerase chain reaction to search for Herpes viruses in uveitic and healthy eyes: a South African perspective.
Article in African health sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Antiviral Therapy for Varicella Zoster Virus (VZV) and Herpes Simplex Virus (HSV)-Induced Anterior Uveitis: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Varicella zoster virus-associated morbidity and mortality in Africa - a systematic review.BMC infectious diseases · 2017Pooled it
- Possible viral agents to consider in the differential diagnosis of blepharoconjunctivitis.World journal of virology · 2024Article
- Absence of Herpesvirus DNA in Aqueous Humor from Asymptomatic Subjects.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Herpesviridae prevalence in aqueous humor using PCR.Clinical ophthalmology (Auckland, N.Z.) · 2018Article
- Efficacy and safety of an extemporaneous preparation of 2% ganciclovir eye drops in CMV anterior uveitis.BMJ open ophthalmology · 2017Article
- Hepatitis, HIV and Ebola: light at the end of the tunnel.African health sciences · 2015Article
- The Value of an Appreciation of Clinical Profiles in Communities as Aide-mémoire When Faced with Difficult Ophthalmic Diagnoses.Middle East African journal of ophthalmologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo analyse aqueous polymerase chain reaction (PCR) results in patients diagnosed with undifferentiated uveitis and determine prevalence of herpesviridae in non-uveitic patients undergoing routine cataract extraction.
designRetrospective comparative case series and prospective cross-sectional study. SUBJECTS: 72 patients with idiopathic uveitis and 57 surgical patients.
methodsDiagnostic aqueous paracentesis with PCR testing for 6 herpes viridae in uveitic patients. Anterior chamber paracentesis immediately pre-operative in the prospective arm, with PCR testing.
resultsIn the retrospective review we had a 47.2% positive PCR yield. Data analysis revealed a statistically significant correlation between a positive yield and being HIV+ (p=0.018); between an EBV+ yield and being HIV+ (p= 0.026) and a CMV+ result and being HIV+ (p=0.032). Posterior uveitis (p=0.014) and symptoms <30 days (p= 0.0014) had a statistically significant yield. In the prospective arm of the study: all 57 patients were HIV- and all aqueous samples were negative for the 6 herpesviridae.
conclusionWe recommend PCR testing for Herpesviridae as a safe second line test for patients with undifferentiated uveitis. We were unable to establish prevalence and suggest that the idea of a commensal herpes virus is unlikely if the blood-ocular barrier is intact.
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