ArticleJournal of physical therapy science2016
Effects of topical oxygen therapy on ischemic wound healing.
Article in Journal of physical therapy science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05427760 (Effect of Using Oxygen on the Diaper Dermatitis in Infants), which is not on this map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Using Oxygen on the Diaper Dermatitis in Infants
Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Flap Salvage Using Topical Oxygen Therapy (Natrox) in a Pediatric Foot Degloving Injury: A Case Report.Journal of clinical medicine · 2026Article
- Topical Oxygenation Improves Microvascularity in a Human Ex Vivo Palatal Tissue Model: A Histological Analysis.Dentistry journal · 2025Article
- Injectable Antioxidant and Oxygen-Releasing Lignin Composites to Promote Wound Healing.ACS applied materials & interfaces · 2023Article
- The Effect of Topical Oxygen Therapy in Horses Affected with Mycosis of the Guttural Pouch: An Experimental Pilot Study and a Case Series.Animals : an open access journal from MDPI · 2021Article
- Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2018Review
- Topical oxygen therapy & micro/nanobubbles: a new modality for tissue oxygen delivery.International wound journal · 2018Review
- Does Continuous Diffusion of Oxygen Improve Diabetic Foot Ulcer Healing?Journal of diabetes science and technology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
[Purpose] This study evaluated the effects of topical oxygen therapy on the hind limb wounds of rats under ischemic conditions. [Subjects and Methods] Twelve injured rats were treated with topical oxygen on skin wounds located on the hind limb and compared with twelve injured control rats. Indexes including gross morphology of the wound, wound healing time, wound healing rate, and histological and immunohistochemical staining of sections of wound tissue were examined at different time points after intervention. [Results] The wound healing time was shorter in the topical oxygen therapy group than the control group. The wound healing rate and granulation tissue formation in the topical oxygen therapy group showed significant improvement on days 3, 7, and 14. Through van Gieson staining, the accumulation of collagen fiber in the topical oxygen therapy group was found to have improved when compared with the control group on day 7. Through semiquantitative immunohistochemical staining, many more new vessels were found in the topical oxygen therapy group compared with the model control group on day 7. [Conclusion] The results of the experiment showed that topical oxygen therapy improved ischemic wound healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.