ReviewAnesthesia, essays and researches
A brief review on the efficacy of different possible and nonpharmacological techniques in eliminating discomfort of local anesthesia injection during dental procedures.
Review in Anesthesia, essays and researches. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment Prior to Injection and Biopsy of the Vulva
A Randomized Controlled Trial Evaluating Three Non-invasive Analgesic Techniques in Pain Prevention During Injections
Efficacy of Ethyl Chloride Topical Anesthesia Application on the Pain Perception During Intra-oral Injections in Children in Comparison to Benzocaine Gel- a Single-blinded Randomized Controlled Trial.
Effectiveness of Pre Injection Use of Cryoanesthesia as Compared to Topical Anesthetic Gel in Reducing Pain Perception During Palatal Injections
Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Comparing the effect of photobiostimulation, pressure and topical anesthetic gel on reducing pain during maxillary infiltration injection: a clinical trial study.BMC oral health · 2026Trial
- Efficacy of two behavioural management techniques during inferior alveolar nerve block administration in pre-school children: a randomised clinical trial.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2023Trial
- Effect of Transcodent painless needles on injection pain in maxillary anterior infiltration: a split-mouth controlled randomized clinical trial.Clinical and experimental dental research · 2022Trial
- Comparison of two behavior management techniques used during mandibular block anesthesia among preschool children: a randomized clinical trial.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2021Trial
- Comparison of Lidocaine Spray and Lidocaine Ice Popsicle in Patients Undergoing Unsedated Esophagogastroduodenoscopy: A Single Center Prospective Randomized Controlled Trial.Clinical and experimental gastroenterology · 2021Trial
- Ice versus lidocaine 5% gel for topical anaesthesia of oral mucosa - a randomized cross-over study.BMC anesthesiology · 2019Trial
- Effect of photobiomodulation on pain perception during local anesthesia in children: a systematic review and meta-analysis.Journal of dental anesthesia and pain medicine · 2026Review
- Topical anesthetics methods used to reduce needle pain/discomfort prior to local anesthesia in children and adolescents: a scoping review.Evidence-based dentistry · 2025Article
- Clinical anxiety among a sample of dental students in South Sinai.BMC oral health · 2025Article
- Comparative Efficacy of MadaJetFrontiers in dentistry · 2025Article
- AnInternational journal of clinical pediatric dentistry · 2024Article
- Effectiveness of pre-injection use of cryoanesthesia as compared to topical anesthetic gel in reducing pain perception during palatal injections: a randomized controlled trial.Journal of dental anesthesia and pain medicine · 2024Article
- Cryoanesthesia with ethyl chloride spray versus 5% lidocaine gel in alleviating oral local anesthetic injection pain for buccal anaesthesia: A randomized clinical (controlled) trial.Journal of dental research, dental clinics, dental prospects · 2023Article
- Anesthetic efficacy of Gow-Gates versus inferior alveolar nerve block for irreversible pulpitis: a systematic quantitative review.Journal of dental anesthesia and pain medicine · 2021Review
- Anesthetic efficacy of single buccal infiltration of 4% articaine compared to routine inferior alveolar nerve block with 2% lidocaine during bilateral extraction of mandibular primary molars: a randomized controlled trial.Journal of dental anesthesia and pain medicine · 2021Article
- The effect of pre-cooling versus topical anesthesia on pain perception during palatal injections in children aged 7-9 years: a randomized split-mouth crossover clinical trial.Journal of dental anesthesia and pain medicine · 2020Article
- Effect of warming local anesthesia solutions before intraoral administration in dentistry: a systematic review.Journal of dental anesthesia and pain medicine · 2020Review
- Pain perception and efficacy of local analgesia using 2% lignocaine, buffered lignocaine, and 4% articaine in pediatric dental procedures.Journal of dental anesthesia and pain medicine · 2019Article
- Efficacy of dental local anesthetics: A review.Journal of dental anesthesia and pain medicine · 2018Review
- The assessment of ice pack effect in pain reduction during digital nerve block: A randomized clinical study.Turkish journal of emergency medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dental anxiety and fear of needle injection is one of the most common problems encountered by dental practitioners, especially in the pediatric patient. In consequences, it might affect the patient's quality of life. Several methods are suggested to lower the discomfort of local anesthesia injection during dental procedures. Desensitization of injection site is one of the recommended strategies. Among chemical anesthetic topical agents that are effective but might have allergic side effects, using some nonpharmacological and safe techniques might be useful. This study aimed to overview the efficacy of using cooling techniques, mostly by ice or popsicles, warming or pH buffering of drug, and using modern devices to diminish the discomfort of local anesthesia injection during dental procedures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.