Evidence map›Paper›PMID 26957624›Full record

ArticlePoultry science2016

Distribution of α-transducin and α-gustducin immunoreactive cells in the chicken (Gallus domesticus) gastrointestinal tract.

M Mazzoni, C Bombardi, C Vallorani, F Sirri, R De Giorgio, G Caio, A Grandis, C Sternini, P Clavenzani

Open access · hybridAbstract read
In one paragraph

Article in Poultry science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Bitter taste receptors as sensors of gut luminal contents.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  2. Bitter Taste Perception in Chickens.The journal of poultry science · 2022
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

M MazzoniDepartment of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia (BO), Italy. Electronic address: m.mazzoni@unibo.it.
C BombardiDepartment of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia (BO), Italy.
C ValloraniDepartment of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia (BO), Italy.
F SirriDepartment of Agricultural and Food Sciences, University of Bologna, Ozzano Emilia (BO), Italy.
R De GiorgioDepartment of Medical and Surgical Sciences, University of Bologna (BO), Italy.
G CaioDepartment of Medical and Surgical Sciences, University of Bologna (BO), Italy.
A GrandisDepartment of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia (BO), Italy.
C SterniniCURE/DDRC, Division of Digestive Diseases, Departments Medicine and Neurobiology, David Geffen School of Medicine, UCLA, Los Angeles; Veterans Administration Greater Los Angeles Health System, Los Angeles, CA.
P ClavenzaniDepartment of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia (BO), Italy.
University of Bologna · ITUniversity of California, Los Angeles · US

Funding

Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
Extragustatory Functions of Bitter Taste ReceptorsR01DK098447 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI STERNINI, CATIA · 2015 to 2018
$1.4M
NIDDK NIH HHS P30 DK041301NIDDK NIH HHS R01 DK098447
6 · The paper itself

Abstract

The expression and distribution patterns of the taste signaling molecules, α-gustducin (Gαgust) and α-transducin (Gαtran) G-protein subunits, were studied in the gastrointestinal tract of the chicken (Gallus domesticus) using the immunohistochemical method. Gαgust and Gαtran immunoreactive (-IR) cells were observed in the mucosal layer of all examined segments, except the esophagus, crop, and the saccus cranialis of the gizzard. The highest numbers of Gαgust and Gαtran-IR cells were found in the proventriculus glands and along the villi of the pyloric, duodenum, and rectal mucosa. Gαgust and Gαtran-IR cells located in the villi of the jejunum, ileum, and cloaca were much less numerous, while only a few Gαgust and Gαtran-IR cells were detected in the mucosa of the proventriculus and cecum. In the crypts, IR cells were observed in the small and large intestine as well as in the cloaca. Gαgust and Gαtran-IR cells displayed elongated ("bottle-" or "pear-like") or rounded shape. The demonstration of Gαgust and Gαtran expression provides evidence for taste receptor mediated mucosal chemosensitivity in the chicken gastrointestinal tract.

Indexed as

Signal TransductionAnimalsAvian ProteinsChickensGastrointestinal TractGene ExpressionMaleOrgan SpecificityTasteTransducinAvian ProteinsgustducinTransducinchemosensingchickengastrointestinal tractα-gustducinα-transducin

Identifiers

PMID26957624
PMCPMC4988557
OpenAlexW2293918670

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.