ArticleProceedings of the National Academy of Sciences of the United States of America2016
Energy landscape in protein folding and unfolding.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Sequence-encoded dynamics diversify allostery within a conserved protein scaffold.Protein science : a publication of the Protein Society · 2026Article
- Eyring-Polanyi Rate Theory for the Homogeneous Nucleation of Organic Crystals from Solution.Crystal growth & design · 2026Article
- FitFoldData: A Web-Based Toolkit for Circular Dichroism and Differential Scanning Calorimetry Data Analysis of Protein Thermal Denaturation.ACS omega · 2025Article
- Computational study of terahertz-driven controllable molecular isomerization.Nature communications · 2025Article
- Small Heat Shock Proteins: Protein Aggregation Amelioration and Neuro- and Age-Protective Roles.International journal of molecular sciences · 2025Review
- Structural characterization of DNA-binding domain of essential mammalian protein TTF 1.Bioscience reports · 2024Article
- DNA-based assay for calorimetric determination of protein concentrations in pure or mixed solutions.PloS one · 2024Article
- Protein conformational ensembles in function: roles and mechanisms.RSC chemical biology · 2023Review
- Calorimetric analysis using DNA thermal stability to determine protein concentration.bioRxiv : the preprint server for biology · 2023Article
- The Hydrophobic Effect Studied by Using Interacting Colloidal Suspensions.International journal of molecular sciences · 2023Article
- Structure-Guided Approach to Discover Tuberosin as a Potent Activator of Pyruvate Kinase M2, Targeting Cancer Therapy.International journal of molecular sciences · 2022Article
- Hydrophilic and Hydrophobic Effects on the Structure and Themodynamic Properties of Confined Water: Water in Solutions.International journal of molecular sciences · 2021Article
- An experimental approach probing the conformational transitions and energy landscape of antibodies: a glimmer of hope for reviving lost therapeutic candidates using ionic liquid.Chemical science · 2021Article
- Implicit water model within the Zimm-Bragg approach to analyze experimental data for heat and cold denaturation of proteins.Communications chemistry · 2021Article
- Mesophilic Pyrophosphatase Function at High Temperature: A Molecular Dynamics Simulation Study.Biophysical journal · 2020Article
- Circuit Topology Analysis of Polymer Folding Reactions.ACS central science · 2020Review
- The Current Status of Genes and Genetic Testing in Emergency Medicine: A Narrative Review.Advanced journal of emergency medicine · 2020Review
- Non-Arrhenius Reaction-Diffusion Kinetics for Protein Inactivation over a Large Temperature Range.ACS nano · 2019Article
- Alpha-Synuclein Is a Target of Fic-Mediated Adenylylation/AMPylation: Possible Implications for Parkinson's Disease.Journal of molecular biology · 2019Article
- The Role of Hydrogen Bonding in the Folding/Unfolding Process of Hydrated Lysozyme: A Review of Recent NMR and FTIR Results.International journal of molecular sciences · 2018Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We use (1)H NMR to probe the energy landscape in the protein folding and unfolding process. Using the scheme ⇄ reversible unfolded (intermediate) → irreversible unfolded (denatured) state, we study the thermal denaturation of hydrated lysozyme that occurs when the temperature is increased. Using thermal cycles in the range 295 < T < 365 K and following different trajectories along the protein energy surface, we observe that the hydrophilic (the amide NH) and hydrophobic (methyl CH3 and methine CH) peptide groups evolve and exhibit different behaviors. We also discuss the role of water and hydrogen bonding in the protein configurational stability.
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