Evidence map›Paper›PMID 26957492›Full record

ArticleEuropean journal of pediatrics2016

Association of cytokine gene polymorphisms and risk factors with otitis media proneness in children.

Olivera Miljanović, Bojana Cikota-Aleksić, Dragan Likić, Danilo Vojvodić, Ognjen Jovićević, Zvonko Magić

Abstract read
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Article in European journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 21 citations in OpenAlex.

  1. Panel 7 - Pathogenesis of otitis media - a review of the literature between 2015 and 2019.International journal of pediatric otorhinolaryngology · 2020
    Review
  2. Panel 2- recent advance in otitis media bioinformatics.International journal of pediatric otorhinolaryngology · 2020
    Review
  3. [Epigenetic effects of human breastfeeding].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Olivera MiljanovićCenter for medical genetic and immunology, Clinical Center of Montenegro, Str. Ljubljanska BB, 81 000, Podgorica, Montenegro. oliveram@ac.me.
Bojana Cikota-AleksićMilitary Medical Academy, Institute of Medical Research, Belgrade, Serbia.
Dragan LikićDepartment for Anesthesiology, Department for Otorhinolaryngology, Clinical Center of Montenegro, Institute for Children Diseases, Podgorica, Montenegro.
Danilo VojvodićMilitary Medical Academy, Institute of Medical Research, Belgrade, Serbia.
Ognjen JovićevićDepartment for Anesthesiology, Department for Otorhinolaryngology, Clinical Center of Montenegro, Institute for Children Diseases, Podgorica, Montenegro.
Zvonko MagićMilitary Medical Academy, Institute of Medical Research, Belgrade, Serbia.
Military Medical Academy · RSUniversity of Montenegro · ME

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledIn order to assess the association between gene polymorphisms and otitis media (OM) proneness, tumor necrosis factor alpha (TNFA) -308, interleukin (IL) 10-1082 and -3575, IL6 -597, IL2 -330, and CD14 -159 genotyping was performed in 58 OM-prone children and 85 controls who were exposed to similar number and frequency of environmental and host risk factors. The frequencies of genotypes (wild type vs. genotypes containing at least one polymorphic allele) were not significantly different between groups, except for IL10 -1082. Polymorphic genotypes IL10 -1082 GA and GG were more frequent in OM-prone children than in control group (RR 1.145, 95 % CI 1.011-1.298; p = 0.047). However, logistic regression did not confirm IL10 -1082 polymorphic genotypes as an independent risk factor for OM proneness.

conclusionThe present study indicates that high-producing IL10 -1082 GA/GG genotypes may increase the risk for OM proneness in its carriers when exposed to other environmental/host risk factors (day care attendance, passive smoking, male sex, respiratory infections, and atopic manifestations). This study revealed no significant independent genetic association, but the lack of breastfeeding in infancy was found to be the only independent risk factor for development of OM-prone phenotype, implying that breastfeeding had a protective role in development of susceptibility to OM. WHAT IS KNOWN: • The pathogenesis of OM is of multifactorial nature, dependent on infection, environmental factors, and immune response of the child. • Cytokines and CD14 play an important role in the presentation and clinical course of otitis media, but a clear link with otitis media proneness was not established. What is new: • This is the first clinical and genetic study on Montenegrin children with the otitis media-prone phenotype. • The study revealed that high-producing IL10 -1082 genotypes may influence otitis media proneness in children exposed to other environmental/host risk factors.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAge DistributionCase-Control StudiesChildChild, PreschoolChi-Square DistributionFemaleGenotypeHumansInterleukin-10Interleukin-2Interleukin-6Lipopolysaccharide ReceptorsLogistic ModelsMaleInterleukin-10Interleukin-2Interleukin-6Lipopolysaccharide ReceptorsTumor Necrosis Factor-alphaCytokinesGene polymorphismsOtitis mediaOtitis media pronenessRisk factors

Identifiers

PMID26957492
OpenAlexW2296416487

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.