ArticleEcoHealth2016
White-Nose Syndrome Disease Severity and a Comparison of Diagnostic Methods.
Article in EcoHealth, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 44 citations in OpenAlex.
- The importance of peripheral populations in the face of novel environmental change.Proceedings. Biological sciences · 2025Article
- Sex-biased infections scale to population impacts for an emerging wildlife disease.Proceedings. Biological sciences · 2023Article
- Environmental transmission of Pseudogymnoascus destructans to hibernating little brown bats.Scientific reports · 2023Article
- Higher white-nose syndrome fungal isolate yields from UV-guided wing biopsies compared with skin swabs and optimal culture media.BMC veterinary research · 2023Article
- Contact-independent exposure toPeerJ · 2023Article
- Article
- Gaussian process forecastsEcology and evolution · 2022Article
- Experimental inoculation trial to determine the effects of temperature and humidity on White-nose Syndrome in hibernating bats.Scientific reports · 2022Article
- Development of a multi-year white-nose syndrome mitigation strategy using antifungal volatile organic compounds.PloS one · 2022Article
- Mobility and infectiousness in the spatial spread of an emerging fungal pathogen.The Journal of animal ecology · 2021Article
- Ecology and impacts of white-nose syndrome on bats.Nature reviews. Microbiology · 2021Review
- Continued preference for suboptimal habitat reduces bat survival with white-nose syndrome.Nature communications · 2021Article
- Transcriptional host-pathogen responses ofVirulence · 2020Article
- COUNTCOLORS, AN R PACKAGE FOR QUANTIFICATION OF THE FLUORESCENCE EMITTED BY PSEUDOGYMNOASCUS DESTRUCTANS LESIONS ON THE WING MEMBRANES OF HIBERNATING BATS.Journal of wildlife diseases · 2020Article
- Assessment of the Portable C-320 Electronic Nose for Discrimination of Nine Insectivorous Bat Species: Implications for Monitoring White-Nose Syndrome.Biosensors · 2020Article
- Antifungal Potential of the Skin Microbiota of Hibernating Big Brown Bats (Frontiers in microbiology · 2020Article
- Field trial of a probiotic bacteria to protect bats from white-nose syndrome.Scientific reports · 2019Article
- An experimental test of energy and electrolyte supplementation as a mitigation strategy for white-nose syndrome.Conservation physiology · 2019Article
- Alterations in the health of hibernating bats under pathogen pressure.Scientific reports · 2018Article
- Body temperatures of hibernating little brown bats reveal pronounced behavioural activity during deep torpor and suggest a fever response during white-nose syndrome.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
White-nose syndrome is caused by the fungus Pseudogymnoascus destructans and has killed millions of hibernating bats in North America but the pathophysiology of the disease remains poorly understood. Our objectives were to (1) assess non-destructive diagnostic methods for P. destructans infection compared to histopathology, the current gold-standard, and (2) to evaluate potential metrics of disease severity. We used data from three captive inoculation experiments involving 181 little brown bats (Myotis lucifugus) to compare histopathology, quantitative PCR (qPCR), and ultraviolet fluorescence as diagnostic methods of P. destructans infection. To assess disease severity, we considered two histology metrics (wing area with fungal hyphae, area of dermal necrosis), P. destructans fungal load (qPCR), ultraviolet fluorescence, and blood chemistry (hematocrit, sodium, glucose, pCO2, and bicarbonate). Quantitative PCR was most effective for early detection of P. destructans, while all three methods were comparable in severe infections. Correlations among hyphae and necrosis scores, qPCR, ultraviolet fluorescence, blood chemistry, and hibernation duration indicate a multi-stage pattern of disease. Disruptions of homeostasis occurred rapidly in late hibernation. Our results provide valuable information about the use of non-destructive techniques for monitoring, and provide novel insight into the pathophysiology of white-nose syndrome, with implications for developing and implementing potential mitigation strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.