ArticleBMC microbiology2016
Identification of novel surfactin derivatives from NRPS modification of Bacillus subtilis and its antifungal activity against Fusarium moniliforme.
Article in BMC microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- The Surfactin-Like Lipopeptides FromFrontiers in bioengineering and biotechnology · 2021Pooled it
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- Biopesticidal Properties of the ProbioticToxins · 2026Article
- Interactions of PGPR from the phylum bacillota with native rhizosphere microbiota: current insights and future perspectives.World journal of microbiology & biotechnology · 2026Review
- Synthetic Linear Lipopeptides and Lipopeptoids Induce Apoptosis and Oxidative Stress: In Vitro Cytotoxicity and SAR Evaluation Against Cancer Cell Lines.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Advanced bifunctional nanotherapeutics display multi-tiered defense againstMaterials today. Bio · 2025Article
- Presence of polyketide synthases and nonribosomal peptide synthetase in culturable bacteria associated with Aplysina fulva and Aplysina caissara (Porifera).Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Antimicrobial Activity ofInternational journal of molecular sciences · 2025Review
- Application of Combined Irradiation Mutagenesis Technique for Hyperproduction of Surfactin inInternational journal of microbiology · 2025Article
- Mechanisms and Impact of Rhizosphere Microbial Metabolites on Crop Health, Traits, Functional Components: A Comprehensive Review.Molecules (Basel, Switzerland) · 2024Review
- Molecular Mechanism: Inhibition ofMolecules (Basel, Switzerland) · 2024Article
- Antibacterial, Antifungal, and Cytotoxic Effects of EndophyticBiomedicines · 2024Article
- Seed Priming with RhizosphericToxins · 2024Article
- Bdelloid rotifers deploy horizontally acquired biosynthetic genes against a fungal pathogen.Nature communications · 2024Article
- An insight into the utilization of microbial biosurfactants pertaining to their industrial applications in the food sector.Food science and biotechnology · 2024Review
- Antifungal Compounds from Microbial Symbionts Associated with Aquatic Animals and Cellular Targets: A Review.Pathogens (Basel, Switzerland) · 2023Review
- Mechanisms of Surfactin fromJournal of fungi (Basel, Switzerland) · 2023Article
- Antagonistic Activity of Pseudomonas fluorescens Strain X1 Against Different Fusaria and it's In Vivo Analysis Against Fusarium udum Infected Pigeon Pea.Current microbiology · 2023Article
- MALDI mass spectrometry-based identification of antifungal molecules from endophyticCurrent research in microbial sciences · 2023Article
- Translocation of subunit PPSE in plipastatin synthase and synthesis of novel lipopeptides.Synthetic and systems biotechnology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBacillus subtilis strain PB2-L1 produces the lipopeptide surfactin, a highly potent biosurfactant synthesized by a large multimodular nonribosomal peptide synthetase (NRPS). In the present study, the modules SrfA-A-Leu, SrfA-B-Asp, and SrfA-B-Leu from surfactin NRPS in B. subtilis BP2-L1 were successfully knocked-out using a temperature-sensitive plasmid, pKS2-mediated-based, homologous, recombination method.
resultsThree novel surfactin products were produced, individually lacking amino acid Leu-3, Asp-5, or Leu-6. These surfactins were detected, isolated, and characterized by HPLC and LC-FTICR-MS/MS. In comparison with native surfactin, [∆Leu(3)]surfactin and [∆Leu(6)]surfactin showed evidence of reduced toxicity, while [∆Asp(5)]surfactin showed stronger inhibition than native surfactin against B. pumilus and Micrococcus luteus. These results showed that the minimum inhibitory concentration of [∆Leu(6)]surfactin for Fusarium moniliforme was 50 μg/mL, such that [∆Leu(6)]surfactin could lead to mycelium projection, cell damage, and leakage of nucleic acids and protein. These factors all contributed to stimulating apoptosis in F. moniliforme.
conclusionsThe present results revealed that [∆Leu(6)]surfactin showed a significant antifungal activity against F. moniliforme and might successfully be employed to control fungal food contamination and improve food safety.
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