Evidence map›Paper›PMID 26957306›Full record

ReviewCurrent hypertension reports2016

Neural Control of Non-vasomotor Organs in Hypertension.

Chansol Hurr, Colin N Young

Abstract readReview
In one paragraph

Review in Current hypertension reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Maternal High-Fat Diet and Offspring Hypertension.International journal of molecular sciences · 2022
    Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Neurogenic hypertension: pathophysiology, diagnosis and management.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2018
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Chansol HurrDepartment of Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University, 2300 Eye Street NW, 448 Ross Hall, Washington, D.C., 20037, USA.
Colin N YoungDepartment of Pharmacology and Physiology, School of Medicine and Health Sciences, The George Washington University, 2300 Eye Street NW, 448 Ross Hall, Washington, D.C., 20037, USA. colinyoung@gwu.edu.

Funding

Forebrain-hypothalamic mechanisms in obesity-induced hypertensionR01HL141393 · NHLBI · GEORGE WASHINGTON UNIVERSITY · PI YOUNG, COLIN NEAL · 2018 to 2022
$2.4M
Role of Central Neural NFkB and ER Stress in Obesity-induced HypertensionR00HL116776 · NHLBI · GEORGE WASHINGTON UNIVERSITY · PI YOUNG, COLIN NEAL · 2015 to 2017
$747k
Role of Central Neural NFkB and ER Stress in Obesity-induced HypertensionK99HL116776 · NHLBI · CORNELL UNIVERSITY · PI YOUNG, COLIN NEAL · 2013 to 2014
$174k
NHLBI NIH HHS HL116776)NHLBI NIH HHS K99 HL116776NHLBI NIH HHS R00 HL116776NHLBI NIH HHS R01 HL141393
6 · The paper itself

Abstract

Hypertension affects over 25 % of the population with the incidence continuing to rise, due in part to the growing obesity epidemic. Chronic elevations in sympathetic nerve activity (SNA) are a hallmark of the disease and contribute to elevations in blood pressure through influences on the vasculature, kidney, and heart (i.e., neurogenic hypertension). In this regard, a number of central nervous system mechanisms and neural pathways have emerged as crucial in chronically elevating SNA. However, it is important to consider that "sympathetic signatures" are present, with differential increases in SNA to regional organs that are dependent upon the disease progression. Here, we discuss recent findings on the central nervous system mechanisms and autonomic regulatory networks involved in neurogenic hypertension, in both non-obesity- and obesity-associated hypertension, with an emphasis on angiotensin-II, salt, oxidative and endoplasmic reticulum stress, inflammation, and the adipokine leptin.

Indexed as

Angiotensin IIAnimalsBlood PressureCentral Nervous SystemHumansHypertensionObesityReactive Oxygen SpeciesAngiotensin IIReactive Oxygen SpeciesAutonomicBlood pressureBrainCentral nervous systemSympathetic nerve activity

Identifiers

PMID26957306
PMCPMC5078991

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.