ArticleMolecular medicine reports2016
Impaired function of the intestinal barrier in a novel sub-health rat model.
Article in Molecular medicine reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
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- Cyanidin-3,5-O-Glucoside Alleviates DSS-Induced Colon Barrier Dysfunction and Fibrosis Through Autophagy-Associated Pathway-Mediated Inflammation Repression in a C57BL/6J Mouse Model.Applied biochemistry and biotechnology · 2026Article
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- Nanozymes modulate probiotic tryptophan metabolism to prevent Salmonella infection in mammalian models.Nature microbiology · 2025Article
- Colour Preference and Healing in Digital Roaming Landscape: A Case Study of Mental Subhealth Populations.International journal of environmental research and public health · 2022Article
- Regulatory effects ofFrontiers in microbiology · 2022Article
- [Exploring effects of natural hyperoxic environment on liver lipid metabolism based on the bile acid-farnesoid X receptor pathway in sub-healthy rats].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2021Article
- Schisantherin A improves learning and memory abilities partly through regulating the Nrf2/Keap1/ARE signaling pathway in chronic fatigue mice.Experimental and therapeutic medicine · 2021Article
- Association Between Passive Smoking and Health Among Chinese Nurses: A Cross-Sectional Study.Frontiers in public health · 2021Article
- The Effect of Psychological Contract Combined With Stress and Health on Employees' Management Behavior.Frontiers in psychology · 2021Article
- CADM1 enhances intestinal barrier function in a rat model of mild inflammatory bowel disease by inhibiting the STAT3 signaling pathway.Journal of bioenergetics and biomembranes · 2020Article
- Article
- LPS Inhibits Fatty Acid Absorption in Enterocytes through TNF-α Secreted by Macrophages.Cells · 2019Article
- Raw Bowl Tea (Tuocha) Polyphenol Prevention of Nonalcoholic Fatty Liver Disease by Regulating Intestinal Function in Mice.Biomolecules · 2019Article
- Protective effect of aplysin on liver tissue and the gut microbiota in alcohol-fed rats.PloS one · 2017Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Sub-health is a state featuring a deterioration in physiological function between health and illness, and the sub-health condition has surfaced as life-threatening in humans. The aim of the present study was to establish a sub-health model in rats, and investigate the function of the intestinal barrier in the sub-health rats and rats following intervention. To establish a sub‑health model, the rats were subjected to a high‑fat and sugar diet, motion restriction and chronic stress. Their serum glucose and triglyceride levels, immune function and adaptability were then measured. The levels of diamine oxidase and D‑lactic acid in the plasma were analyzed as markers of the intestinal permeability. The protein and mRNA expression levels of anti‑apoptotic YWHAZ in the colonic tissue was detected using immunohistochemical and reverse transcription‑quantitative polymerase chain reaction analyses In the present study, the sub‑health rat model was successfully established, and sub‑health factors increased the intestinal permeability and reduced the expression of YWHAZ. Providing sub‑health rats with normal living conditions did not improve the function of the intestinal barrier. In conclusion, the results of the present study demonstrated that intestinal disorders in the sub‑health rat model may result from the damage caused by reduce intestinal barrier function as well as the decreased expression levels of YWHAZ. Additionally, rats in the sub‑health condition did not recover following subsequent exposure to normal living conditions, suggesting that certain exercises or medical intervention may be necessary to improve sub-health symptoms.
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