ArticleThe Journal of antibiotics2016
The use of fluorescently-tagged apoptolidins in cellular uptake and response studies.
Katherine M Chong, Nalin Leelatian, Sean M Deguire, Asa A Brockman, David Earl, Rebecca A Ihrie, Jonathan M Irish, Brian O Bachmann, Gary A Sulikowski
Abstract read
In one paragraphArticle in The Journal of antibiotics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors.
Katherine M ChongVanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, TN, USA.
Nalin LeelatianVanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, TN, USA.
Sean M DeguireVanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, TN, USA.
Asa A BrockmanDepartment of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, USA.
David EarlVanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, TN, USA.
Rebecca A IhrieDepartment of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Jonathan M IrishVanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0001-9428-8866 Brian O BachmannVanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, TN, USA.
Gary A SulikowskiVanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, TN, USA.
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8MChemistry-Biology Interface Training GrantT32GM065086 · NIGMS · VANDERBILT UNIVERSITY · PI BACHMANN, BRIAN O, SULIKOWSKI, GARY ALLEN · 2002 to 2022
$7.0MSynthetic/Mechanistic Investigations of Antitumor AgentsR01CA059515 · NCI · VANDERBILT UNIVERSITY · PI SULIKOWSKI, GARY ALLEN · 2001 to 2010
$2.2MTargeting the B Cell Receptor Signaling Network in LymphomaR00CA143231 · NCI · VANDERBILT UNIVERSITY · PI IRISH, JONATHAN MICHAEL · 2012 to 2014
$715kSYNTHETIC/MECHANISTIC INVESTIGATIONS OF ANTITUMOR AGENTSR29CA059515 · NCI · TEXAS A&M UNIVERSITY SYSTEM · PI SULIKOWSKI, GARY ALLEN · 1996 to 2000
$107kNCI NIH HHS P30 CA068485NCI NIH HHS P50 CA68485NCI NIH HHS R00 CA143231NCI NIH HHS R01 CA059515NCI NIH HHS R29 CA059515NIGMS NIH HHS T32 GM065086
6 · The paper itselfAbstract
The apoptolidins are glycomacrolide microbial metabolites reported to be selectively cytotoxic against tumor cells. Using fluorescently tagged active derivatives we demonstrate selective uptake of these four tagged glycomacrolides in cancer cells over healthy human blood cells. We also demonstrate the utility of these five fluorescently tagged glycomacrolides in fluorescent flow cytometry to monitor cellular uptake of the six glycomacrolides and cellular response.
Indexed as
A549 CellsBiological TransportCell Line, TumorFlow CytometryFluorescent DyesHumansMacrolidesStaining and LabelingapoptolidinFluorescent DyesMacrolides
Identifiers
PMID26956792
PMCPMC5518790
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