ArticleBMC genomics2016
Transcriptomic responses of the basidiomycete yeast Sporobolomyces sp. to the mycotoxin patulin.
Article in BMC genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Patulin Biodegradation by Rhodosporidiobolus ruineniae and Meyerozyma guilliermondii Isolated From Fruits.MicrobiologyOpen · 2026Article
- Article
- Biocontrol Agents and Natural Feed Supplements as a Safe and Cost-Effective Way for Preventing Health Ailments Provoked by Mycotoxins.Foods (Basel, Switzerland) · 2025Review
- Natural feed additives and bioactive supplements versus chemical additives as a safe and practical approach to combat foodborne mycotoxicoses.Frontiers in nutrition · 2024Review
- Isolation and characterization of filamentous fungi capable of degrading the mycotoxin patulin.MicrobiologyOpen · 2023Article
- Molecular Response ofJournal of fungi (Basel, Switzerland) · 2023Article
- Isolation of a fungal calcineurin A mutant suggests that amoebae can counter-select virulence attributes of microbes.Medical mycology · 2023Article
- Perfume Guns: Potential of Yeast Volatile Organic Compounds in the Biological Control of Mycotoxin-Producing Fungi.Toxins · 2023Review
- Article
- Modulation of extracellularFrontiers in microbiology · 2022Article
- Diversity and phylogeny of basidiomycetous yeasts from plant leaves and soil: Proposal of two new orders, three new families, eight new genera and one hundred and seven new species.Studies in mycology · 2020Article
- Effects of ascorbic acid on patulin in aqueous solution and in cloudy apple juice.Mycotoxin research · 2019Article
- Distinct Transcriptional Changes in Response to Patulin Underlie Toxin Biosorption Differences inToxins · 2019Article
- Review
- Complete Genome Sequence of the Biocontrol Agent Yeast Rhodotorula kratochvilovae Strain LS11.Genome announcements · 2018Article
- The Response ofFrontiers in microbiology · 2018Article
- Toxicological effects of patulin mycotoxin on the mammalian system: an overview.Toxicology research · 2017Review
- Crosstalk between proteins expression and lysine acetylation in response to patulin stress in Rhodotorula mucilaginosa.Scientific reports · 2017Article
- Patulin Degradation by the Biocontrol Yeast Sporobolomyces sp. Is an Inducible Process.Toxins · 2017Article
- Biodegradation Mechanisms of Patulin in Candida guilliermondii: An iTRAQ-Based Proteomic Analysis.Toxins · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundPatulin is a mycotoxin produced by Penicillium expansum, the causal agent of blue mold of stored pome fruits, and several other species of filamentous fungi. This mycotoxin has genotoxic, teratogenic and immunotoxic effects in mammals, and its presence in pome fruits and derived products represents a serious health hazard. Biocontrol agents in the Pucciniomycotina, such as the yeasts Sporobolomyces sp. strain IAM 13481 and Rhodosporidium kratochvilovae strain LS11, are able to resist patulin and degrade it into the less toxic compounds desoxypatulinic acid and ascladiol.
resultsIn this investigation we applied a transcriptomic approach based on RNAseq to annotate the genome of Sporobolomyces sp. IAM 13481 and then study the changes of gene expression in Sporobolomyces sp. exposed to patulin. Patulin treatment leads to ROS production and oxidative stress that result in the activation of stress response mechanisms controlled by transcription factors. Upregulated Sporobolomyces genes were those involved in oxidation-reduction and transport processes, suggesting the activation of defense mechanisms to resist patulin toxicity and expel the mycotoxin out of the cells. Other upregulated genes encoded proteins involved in metabolic processes such as those of the glutathione and thioredoxin systems, which are essential to restore the cellular redox homeostasis. Conversely, patulin treatment decreased the expression of genes involved in the processes of protein synthesis and modification, such as transcription, RNA processing, translation, protein phosphorylation and biosynthesis of amino acids. Also, genes encoding proteins involved in transport of ions, cell division and cell cycle were downregulated. This indicates a reduction of metabolic activity, probably due to the high energy requirement by the cells or metabolic arrest while recovering from the insult caused by patulin toxicity.
conclusionsComplex mechanisms are activated in a biocontrol yeast in response to patulin. The genes identified in this study can pave the way to develop i) a biodetoxification process of patulin in juices and ii) a biosensor for the rapid and cost-effective detection of this mycotoxin.
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