ArticleScientific reports2016
Sepsis-induced elevation in plasma serotonin facilitates endothelial hyperpermeability.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- Complementary and alternative medicine on cognitive defects and neuroinflammation after sepsis.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2024Article
- Basic research and clinical progress of sepsis-associated encephalopathy.Journal of intensive medicine · 2021Review
- Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- Activated Platelets Autocrine 5-Hydroxytryptophan Aggravates Sepsis-Induced Acute Lung Injury by Promoting Neutrophils Extracellular Traps Formation.Frontiers in cell and developmental biology · 2021Article
- Apoptosis signal-regulating kinase 1 regulates immune-mediated thrombocytopenia, thrombosis, and systemic shock.Journal of thrombosis and haemostasis : JTH · 2020Article
- Observational
- Adjunctive granisetron therapy in patients with sepsis or septic shock (GRANTISS): Study protocol for a randomized controlled trial.Medicine · 2019Article
- Role of vimentin in modulating immune cell apoptosis and inflammatory responses in sepsis.Scientific reports · 2019Article
- Frontiers of Serotonin Beyond the Brain.Pharmacological research · 2019Article
- Role of Resveratrol on Indoxyl Sulfate-Induced Endothelial Hyperpermeability via Aryl Hydrocarbon Receptor (AHR)/Src-Dependent Pathway.Oxidative medicine and cellular longevity · 2019Article
- Responses of Plasma Catecholamine, Serotonin, and the Platelet Serotonin Transporter to Cigarette Smoking.Frontiers in neuroscience · 2019Review
- Effects of salbutamol and phlorizin on acute pulmonary inflammation and disease severity in experimental sepsis.PloS one · 2019Article
- The role of platelets in acute kidney injury.Nature reviews. Nephrology · 2018Review
- Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Thymulin, free or bound to PBCA nanoparticles, protects mice against chronic septic inflammation.PloS one · 2018Article
- Clinical implications of the plasma EphA2 receptor level in critically ill patients with septic shock.Scientific reports · 2017Article
- Serotonin transporter protects the placental cells against apoptosis in caspase 3-independent pathway.Journal of cellular physiology · 2017Article
- Peripheral serotonin regulates postoperative intra-abdominal adhesion formation in mice.Scientific reports · 2017Article
- Systemic blockade of P2X7 receptor protects against sepsis-induced intestinal barrier disruption.Scientific reports · 2017Article
- Observational
Corrections and comments
- Retraction · 2019-09-27Error in Image · Original Data and/or Images not Provided and/or not Available ·
- Retracted
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Hyperpermeability of the endothelial barrier and resulting microvascular leakage are a hallmark of sepsis. Our studies describe the mechanism by which serotonin (5-HT) regulates the microvascular permeability during sepsis. The plasma 5-HT levels are significantly elevated in mice made septic by cecal ligation and puncture (CLP). 5-HT-induced permeability of endothelial cells was associated with the phosphorylation of p21 activating kinase (PAK1), PAK1-dependent phosphorylation of vimentin (P-vimentin) filaments, and a strong association between P-vimentin and ve-cadherin. These findings were in good agreement with the findings with the endothelial cells incubated in serum from CLP mice. In vivo, reducing the 5-HT uptake rates with the 5-HT transporter (SERT) inhibitor, paroxetine blocked renal microvascular leakage and the decline in microvascular perfusion. Importantly, mice that lack SERT showed significantly less microvascular dysfunction after CLP. Based on these data, we propose that the increased endothelial 5-HT uptake together with 5-HT signaling disrupts the endothelial barrier function in sepsis. Therefore, regulating intracellular 5-HT levels in endothelial cells represents a novel approach in improving sepsis-associated microvascular dysfunction and leakage. These new findings advance our understanding of the mechanisms underlying cellular responses to intracellular/extracellular 5-HT ratio in sepsis and refine current views of these signaling processes during sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.