Evidence map›Paper›PMID 26956611›Full record

Trial reportPublic health nutrition2016

The effect of providing lipid-based nutrient supplements on morbidity in rural Malawian infants and young children: a randomized controlled trial.

Jaden Bendabenda, Lotta Alho, Ulla Ashorn, Yin Bun Cheung, Kathryn G Dewey, Stephen A Vosti, John Phuka, Kenneth Maleta, Per Ashorn

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Public health nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jaden Bendabenda1Department for International Health,University of Tampere School of Medicine,Tampere,Finland.
Lotta Alho1Department for International Health,University of Tampere School of Medicine,Tampere,Finland.
Ulla Ashorn1Department for International Health,University of Tampere School of Medicine,Tampere,Finland.
Yin Bun Cheung3Centre for Quantitative Medicine,Duke-National University of Singapore Graduate Medical School,Singapore,Singapore.
Kathryn G Dewey4Department of Nutrition,University of California,Davis,Davis,CA,USA.
Stephen A Vosti5Department of Agricultural and Resource Economics,University of California,Davis,Davis,CA,USA.
John Phuka2School of Public Health and Family Medicine,University of Malawi College of Medicine,Postgraduate Building,Mahatma Gandhi Road,Private Bag 360,Blantyre 3,Malawi.
Kenneth Maleta2School of Public Health and Family Medicine,University of Malawi College of Medicine,Postgraduate Building,Mahatma Gandhi Road,Private Bag 360,Blantyre 3,Malawi.
Per Ashorn1Department for International Health,University of Tampere School of Medicine,Tampere,Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSafety of home fortificants in children is uncertain in areas where infections are common. We tested the hypothesis that provision of lipid-based nutrient supplements (LNS) containing Fe does not increase infectious morbidity in children.

designRandomized controlled trial. Infants were randomised to receive 10, 20 or 40 g LNS/d; or no supplement until age 18 months. All LNS contained 6 mg Fe/d. Morbidity outcomes (serious adverse events, non-scheduled visits and guardian-reported morbidity episodes) were compared between control and intervention groups using a non-inferiority margin of 20 %.

settingNamwera and Mangochi catchment areas in rural Malawi. SUBJECTS: Infants aged 6 months (n 1932).

resultsThe enrolled 1932 infants contributed 1306 child-years of follow-up. Baseline characteristics were similar across groups. Compared with the control group, the relative risk (95 % CI) of serious adverse events was 0·71 (0·48, 1·07), 0·67 (0·48, 0·95) and 0·91 (0·66, 1·25) in 10, 20 and 40 g LNS/d groups, respectively. The incidence rate ratio (95 % CI) of non-scheduled visits due to malaria was 1·10 (0·88, 1·37), 1·08 (0·89, 1·31) and 1·21 (1·00, 1·46), and of guardian-reported morbidity episodes was 1·04 (0·96, 1·11), 1·03 (0·97, 1·10) and 1·04 (0·97, 1·10), in the respective LNS groups.

conclusionsProvision of 10 and 20 g LNS/d containing 6 mg Fe/d did not increase morbidity in the children. Provision of 40 g LNS/d did not affect guardian-reported illness episodes but may have increased malaria-related non-scheduled visits.

Indexed as

Dietary SupplementsRural PopulationChild, PreschoolFemaleHumansInfantLipidsMalawiMaleMorbidityLipidsChildrenInfectious disease morbidityIronLipid-based nutrient supplementsLow-income countries

Identifiers

PMID26956611
PMCPMC10271160

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.