Evidence map›Paper›PMID 26956538›Full record

ReviewEuropean journal of nuclear medicine and molecular imaging2016

Diagnostic imaging to detect and evaluate response to therapy in bone metastases from prostate cancer: current modalities and new horizons.

Laura Evangelista, Francesco Bertoldo, Francesco Boccardo, Giario Conti, Ilario Menchi, Francesco Mungai, Umberto Ricardi, Emilio Bombardieri

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in European journal of nuclear medicine and molecular imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 41 citations in OpenAlex.

  1. Quantitative Assessment of Early [Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2017
    Trial
  2. Article
  3. Article
  4. Review
  5. Treatment outcomes of metastasis-directed treatment usingStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2020
    Article
  6. Article
  7. European journal of nuclear medicine and molecular imaging · 2019
    Article
  8. Review
  9. European radiology · 2019
    Article
  10. Comparison of [European journal of nuclear medicine and molecular imaging · 2018
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 1 country.

Laura EvangelistaRadiotherapy and Nuclear Medicine Unit, Veneto Institute of Oncology IOV - IRCCS, Padova, Italy.
Francesco BertoldoDepartment of Internal Medicine, School of Medicine, University of Verona, Verona, Italy.
Francesco BoccardoAcademic Unit of Medical Oncology, IRCCS AOU San Martino-IST (San Martino University Hospital and National Cancer Research Institute), Genoa, Italy.
Giario ContiDepartment of Urology, Sant' Anna Hospital, Como, Italy.
Ilario MenchiDepartment of Diagnostic Imaging, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
Francesco MungaiDepartment of Diagnostic Imaging, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
Umberto RicardiDepartment of Oncology, Radiation Oncology, University of Torino, Torino, Italy.
Emilio BombardieriNuclear Medicine Department, Humanitas Gavazzeni, Via Gavazzeni 31, 24125, Bergamo, Italy. emilio.bombardieri@gavazzeni.it.
Azienda Ospedaliero-Universitaria Careggi · ITHumanitas Gavazzeni · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITOspedale Policlinico San Martino · ITOspedale Sant'Anna · ITUniversity of Turin · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Different therapeutic options for the management of prostate cancer (PC) have been developed, and some are successful in providing crucial improvement in both survival and quality of life, especially in patients with metastatic castration-resistant PC. In this scenario, diverse combinations of radiopharmaceuticals (for targeting bone, cancer cells and receptors) and nuclear medicine modalities (e.g. bone scan, SPECT, SPECT/CT, PET and PET/CT) are now available for imaging bone metastases. Some radiopharmaceuticals are approved, currently available and used in the routine clinical setting, while others are not registered and are still under evaluation, and should therefore be considered experimental. On the other hand, radiologists have other tools, in addition to CT, that can better visualize bone localization and medullary involvement, such as multimodal MRI. In this review, the authors provide an overview of current management of advanced PC and discuss the choice of diagnostic modality for the detection of metastatic skeletal lesions in different phases of the disease. In addition to detection of bone metastases, the evaluation of response to therapy is another critical issue, since it remains one of the most important open questions that a multidisciplinary team faces when optimizing the management of PC. The authors emphasize the role of nuclear modalities that can presently be used in clinical practice, and also look at future perspectives based on relevant clinical data with novel radiopharmaceuticals.

Indexed as

Bone NeoplasmsDiagnostic ImagingHumansMaleNuclear MedicineProstatic NeoplasmsTreatment OutcomeBone metastasesBone scanFunctional imagingMetastatic resistant prostate cancerMRIPET scan

Identifiers

PMID26956538
OpenAlexW2302479109

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.