ArticleInflammation2016
Does Inflammation Mediate the Association Between Obesity and Insulin Resistance?
Article in Inflammation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- The Reporting Quality of Machine Learning Studies on Pediatric Diabetes Mellitus: Systematic Review.Journal of medical Internet research · 2024Pooled it
- Correction of metabolic acidosis improves insulin resistance in chronic kidney disease.BMC nephrology · 2016Trial
- Low-Density Neutrophils Contribute to Subclinical Inflammation in Patients with Type 2 Diabetes.International journal of molecular sciences · 2024Article
- Assessing the impact of body composition, metabolic and oxidative stress parameters on insulin resistance as a prognostic marker for reactive hypoglycemia: a cross-sectional study in overweight, obese, and normal weight individuals.Frontiers in pharmacology · 2024Article
- Effect of Nutritional Deprivation after Sleeve Gastrectomy on Bone Mass, Periostin, Sclerostin and Semaphorin 4D: A Two-Year Longitudinal Study.Nutrients · 2023Article
- Physiopathological mechanisms related to inflammation in obesity and type 2 diabetes mellitus.World journal of experimental medicine · 2023Review
- Irisin as a predictor of bone metabolism in Han Chinese Young Men with pre-diabetic individuals.BMC endocrine disorders · 2022Article
- A predictive regression model of the obesity-related inflammatory status based on gut microbiota composition.International journal of obesity (2005) · 2021Article
- Bicyclol Regulates Hepatic Gluconeogenesis in Rats with Type 2 Diabetes and Non-alcoholic Fatty Liver Disease by Inhibiting Inflammation.Frontiers in pharmacology · 2021Article
- The causal effect of obesity on prediabetes and insulin resistance reveals the important role of adipose tissue in insulin resistance.PLoS genetics · 2020Article
- Visceral and subcutaneous adipose tissue as markers of local and systemic inflammation: a comparison between celiac and obese patients using MRI.Techniques in coloproctology · 2020Article
- Bidirectional Associations between Obesity and Cognitive Function in Midlife Adults: A Longitudinal Study.Nutrients · 2019Article
- Gut microbiota modulate neurobehavior through changes in brain insulin sensitivity and metabolism.Molecular psychiatry · 2018Article
- Low molecular weight galactomannans-based standardized fenugreek seed extract ameliorates high-fat diet-induced obesity in miceRSC advances · 2018Article
- Adiponectin inhibits NLRP3 inflammasome by modulating the AMPK-ROS pathway.International journal of clinical and experimental pathology · 2018Article
- Article
- Interleukin-18 polymorphism as an inflammatory index in metabolic syndrome: A preliminary study.World journal of diabetes · 2017Article
- Insulin Sensitivity and Inflammation Mediate the Impact of Fitness on Cerebrovascular Health in Adolescents.Childhood obesity (Print) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
In adult obesity, low-grade systemic inflammation is considered an important step in the pathogenesis of insulin resistance (IR). The association between obesity and inflammation is less well established in adolescents. Here, we ascertain the importance of inflammation in IR among obese adolescents by utilizing either random forest (RF) classification or mediation analysis approaches. The inflammation balance score, composed of eight pro- and anti-inflammatory makers, as well as most of the individual inflammatory markers differed significantly between lean and overweight/obese. In contrast, adiponectin was the only individual marker selected as a predictor of IR by RF, and the balance score only revealed a medium-to-low importance score. Neither adiponectin nor the inflammation balance score was found to mediate the relationship between obesity and IR. These findings do not support the premise that low-grade systemic inflammation is a key for the expression of IR in the human. Prospective longitudinal studies should confirm these findings.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.