Evidence map›Paper›PMID 26956414›Full record

SynthesisNature communications2016

Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.

Sonja I Berndt, Nicola J Camp, Christine F Skibola, Joseph Vijai, Zhaoming Wang, Jian Gu, Alexandra Nieters, Rachel S Kelly, Karin E Smedby, Alain Monnereau and 116 more

Registry-linked trialOpen access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00039676 (Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of Blood and Lymph Node Malignancy), which is not on this map. Cited by 79 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 4 pooled it
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00039676 active not recruitingnot on this map

Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of Blood and Lymph Node Malignancy

TypeobservationalSponsorNational Cancer Institute (NCI)Ran2002Enrolled1,836ConditionsWaldenstrom Macroglobulinemia, Chronic Lymphocytic Leukemia, Hodgkin Disease, NonHodgkin Lymphoma
3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 4 syntheses or guidelines pooled it, 118 citations in OpenAlex.

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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

126 authors at 20 institutions in 18 countries.

Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Nicola J CampDivision of Hematology and Hematologic Malignancies, Department of Internal Medicine, Huntsman Cancer Institute and University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.
Christine F SkibolaDepartment of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.
Joseph VijaiDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.ORCID http://orcid.org/0000-0002-7933-151X
Zhaoming WangCancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA.
Jian GuDepartment of Epidemiology, MD Anderson Cancer Center, Houston, Texas 77030, USA.
Alexandra NietersCenter for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, 79108 Baden-Württemberg, Germany.
Rachel S KellyDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Karin E SmedbyDepartment of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm 17176, Sweden.
Alain MonnereauEpidemiology of Childhood and Adolescent Cancers Group, INSERM, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), F-94807 Paris, France.
Wendy CozenDepartment of Preventive Medicine, USC Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
Angela CoxDepartment of Oncology, University of Sheffield, Sheffield, South Yorkshire S10 1NS, UK.ORCID http://orcid.org/0000-0002-5138-1099
Sophia S WangDivision of Cancer Etiology, City of Hope Beckman Research Institute, Duarte, California 91030, USA.
Qing LanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Lauren R TerasEpidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA.
Moara MachadoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Meredith YeagerCancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA.
Angela R Brooks-WilsonGenome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3.
Patricia HartgeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Mark P PurdueOntario Health Study, Toronto, Ontario, Canada M5G 0A3.
Brenda M BirmannChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Claire M VajdicCentre for Big Data Research in Health, University of New South Wales, Sydney, New South Wales 2052, Australia.ORCID http://orcid.org/0000-0002-3612-8298
Pierluigi CoccoDepartment of Public Health, Clinical and Molecular Medicine, University of Cagliari, Monserrato, 09042 Cagliari, Italy.
Yawei ZhangDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, USA.
Graham G GilesCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.
Anne Zeleniuch-JacquotteDepartment of Population Health, New York University School of Medicine, New York, New York 10016, USA.
Charles LawrenceWestat, Rockville, Maryland 20850, USA.
Rebecca MontalvanWestat, Rockville, Maryland 20850, USA.
Laurie BurdettCancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA.
Amy HutchinsonCancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA.
Yuanqing YeDepartment of Epidemiology, MD Anderson Cancer Center, Houston, Texas 77030, USA.
Timothy G CallDivision of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Tait D ShanafeltDepartment of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
Anne J NovakDepartment of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
Neil E KayDivision of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Mark LiebowDepartment of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
Julie M CunninghamDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.ORCID http://orcid.org/0000-0002-8159-3025
Cristine AllmerDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Henrik HjalgrimDepartment of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, 2300 Copenhagen, Denmark.
Hans-Olov AdamiDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Mads MelbyeDepartment of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, 2300 Copenhagen, Denmark.
Bengt GlimeliusDepartment of Immunology, Genetics and Pathology, Uppsala University, 75105 Uppsala, Sweden.
Ellen T ChangCenter for Epidemiology and Computational Biology, Health Sciences, Exponent, Inc., Menlo Park, California 94025, USA.
Martha GlennDepartment of Internal Medicine, Huntsman Cancer Institute, Salt Lake City, Utah 84112, USA.
Karen CurtinDepartment of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA.
Lisa A Cannon-AlbrightDepartment of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA.
W Ryan DiverEpidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA.
Brian K LinkDepartment of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA.
George J WeinerDepartment of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA.
Lucia CondeDepartment of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.
Paige M BracciDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94118, USA.
Jacques RibyDepartment of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.
Donna K ArnettDepartment of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.
Degui ZhiDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.
Justin M LeachDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.
Elizabeth A HollyDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94118, USA.
Rebecca D JacksonDivision of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, Ohio 43210, USA.
Lesley F TinkerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98117, USA.
Yolanda BenaventeCancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona 08908, Spain.
Núria SalaUnit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.
Delphine CasabonneUnit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d'Oncologia, IDIBELL, 08908L'Hospitalet de Llobregat, 08908 Barcelona, Spain.
Nikolaus BeckerDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, 69120 Baden-Württemberg, Germany.
Paolo BoffettaThe Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Paul BrennanInternational Agency for Research on Cancer (IARC), 69372 Lyon, France.
Lenka ForetovaDepartment of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU, 656 53 Brno, Czech Republic.
Marc MaynadieEA 4184, Registre des Hémopathies Malignes de Côte d'Or, University of Burgundy and Dijon University Hospital, 21070 Dijon, France.
James McKayInternational Agency for Research on Cancer (IARC), 69372 Lyon, France.
Anthony StainesSchool of Nursing and Human Sciences, Dublin City University, Dublin 9, Ireland.ORCID http://orcid.org/0000-0001-9161-1357
Kari G ChaffeeDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.ORCID http://orcid.org/0000-0002-7313-1875
Sara J AchenbachDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Celine M VachonDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Lynn R GoldinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Sara S StromDepartment of Epidemiology, MD Anderson Cancer Center, Houston, Texas 77030, USA.
Jose F LeisDivision of Hematology/Oncology, Mayo Clinic, Phoenix, Arizona 85054, USA.
J Brice WeinbergDepartment of Medicine, Duke University and VA Medical Centers, Durham, North Carolina 27710, USA.
Neil E CaporasoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Aaron D NormanDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Anneclaire J De RoosDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98117, USA.
Lindsay M MortonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Richard K SeversonDepartment of Family Medicine and Public Health Sciences, Wayne State University, Detroit, Michigan 48201, USA.
Elio RiboliSchool of Public Health, Imperial College London, London W2 1PG, UK.
Paolo VineisMRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.
Rudolph KaaksDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, 69120 Baden-Württemberg, Germany.
Giovanna MasalaMolecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), 50139 Florence, Italy.
Elisabete WeiderpassDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.
María-Dolores ChirlaqueCIBER de Epidemiología y Salud Pública (CIBERESP), 08036 Barcelona, Spain.
Roel C H VermeulenInstitute for Risk Assessment Sciences, Utrecht University, Utrecht, 3508, TD, The Netherlands.
Ruth C TravisCancer Epidemiology Unit, University of Oxford, Oxford OX3 7LF, UK.
Melissa C SoutheyGenetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Melbourne, Victoria 3010, Australia.
Roger L MilneCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Jarmo VirtamoChronic Disease Prevention Unit, National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
Stephanie WeinsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Jacqueline ClavelEpidemiology of Childhood and Adolescent Cancers Group, INSERM, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), F-94807 Paris, France.
Tongzhang ZhengDepartment of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, USA.
Theodore R HolfordDepartment of Biostatistics, Yale School of Public Health, New Haven, Connecticut 06520, USA.
Danylo J VillanoDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Ann MariaDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
John J SpinelliCancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3.
Randy D GascoyneCenter for Lymphoid Cancer, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3.
Joseph M ConnorsCenter for Lymphoid Cancer, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3.
Kimberly A BertrandDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Edward GiovannucciDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Peter KraftDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Anne KrickerSydney School of Public Health, The University of Sydney, Sydney, New South Wales 2006, Australia.
Jenny TurnerFaculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.
Maria Grazia EnnasDepartment of Biomedical Science, University of Cagliari, Monserrato, 09042 Cagliari, Italy.
Giovanni M FerriInterdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.
Lucia MiligiEnvironmental and Occupational Epidemiology Unit, Cancer Prevention and Research Institute (ISPO), 50139 Florence, Italy.
Liming LiangDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Baoshan MaDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Jinyan HuangDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.ORCID http://orcid.org/0000-0002-5546-8626
Simon CrouchDepartment of Health Sciences, University of York, York YO10 5DD, UK.
Ju-Hyun ParkDepartment of Statistics, Dongguk University, Seoul 100-715, Republic of Korea.
Nilanjan ChatterjeeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Kari E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
John A SnowdenDepartment of Oncology, University of Sheffield, Sheffield, South Yorkshire S10 1NS, UK.
Josh WrightDepartment of Oncology, University of Sheffield, Sheffield, South Yorkshire S10 1NS, UK.
Joseph F FraumeniDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Kenneth OffitDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Xifeng WuDepartment of Epidemiology, MD Anderson Cancer Center, Houston, Texas 77030, USA.
Silvia de SanjoseCancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona 08908, Spain.
James R CerhanDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
Susan L SlagerDepartment of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
National Cancer Institute · USMayo Clinic in Florida · USHarvard University · USMayo Clinic · USUniversity of Alabama at Birmingham · USBC Cancer Agency · CAInstitut d'Investigació Biomédica de Bellvitge · ESMemorial Sloan Kettering Cancer Center · USThe University of Texas MD Anderson Cancer Center · USBrigham and Women's Hospital · USThe University of Melbourne · AUUniversity of Utah · USYale University · USAmerican Cancer Society · USCentre international de recherche sur le cancer · FRDélégation Paris 5 · FRFred Hutch Cancer Center · USGerman Cancer Research Center · DERoyal Hallamshire Hospital · GBStatens Serum Institut · DK

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Felicity Enders · 1985 to 2026
$151.3M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI DAVID L RIMM · 1985 to 2026
$85.0M
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jared P Rutter · 1986 to 2026
$72.6M
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Douglas Robert Spitz · 2000 to 2026
$70.0M
The Role of Monocytes in non-Hodgkin LymphomaP50CA097274 · NCI · UNIVERSITY OF IOWA · PI WEINER, GEORGE J. · 2002 to 2021
$45.7M
Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
RESEARCH IN ENVIRONMENTAL HEALTH SCIENCES (CENTER GRANT)P30ES000260 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI COSTA, MAX · 1985 to 2020
$26.1M
The Ohio State University Center for clinical and Translational ScienceUL1TR001070 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2013 to 2017
$22.6M
Cancer Research UK 16491CCR NIH HHS N01 RC037004CCR NIH HHS N01-RC-45035CIHRIntramural NIH HHSNCATS NIH HHS UL1 TR000135NCATS NIH HHS UL1 TR001070NCATS NIH HHS UL1 TR001863NCCDPHP CDC HHS 1U58 DP000807-01NCCDPHP CDC HHS U58 DP000807NCI NIH HHS 30 CA086862NCI NIH HHS 5R01 CA69669-02NCI NIH HHS CA098122NCI NIH HHS CA098566NCI NIH HHS CA1046282NCI NIH HHS CA118444NCI NIH HHS CA148690NCI NIH HHS CA149445NCI NIH HHS CA154643NCI NIH HHS CA165923NCI NIH HHS CA167552NCI NIH HHS CA186107NCI NIH HHS CA49449NCI NIH HHS CA87969NCI NIH HHS CA92153NCI NIH HHS HHSN261201000006CNCI NIH HHS HHSN261201000026CNCI NIH HHS HHSN261201000034CNCI NIH HHS HHSN261201000035CNCI NIH HHS HHSN261201000035INCI NIH HHS HHSN261201000140CNCI NIH HHS K07 CA115687NCI NIH HHS K08 CA134919NCI NIH HHS K08CA134919NCI NIH HHS N01 CN045165NCI NIH HHS N01 CO012400NCI NIH HHS N01 PC065064NCI NIH HHS N01 PC067008NCI NIH HHS N01 PC067009NCI NIH HHS N01 PC067010NCI NIH HHS N01-PC-67009NCI NIH HHS N02-PC-71105NCI NIH HHS NIH CA134674NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA016087NCI NIH HHS P30 CA016359NCI NIH HHS P30 CA042014NCI NIH HHS P30 CA086862NCI NIH HHS P30 CA15083NCI NIH HHS P30 CA42014NCI NIH HHS P50 CA097274NCI NIH HHS P50 CA97274NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA062006NCI NIH HHS R01 CA092153NCI NIH HHS R01 CA098122NCI NIH HHS R01 CA098661NCI NIH HHS R01 CA134674NCI NIH HHS R01 CA148690NCI NIH HHS R01 CA149445NCI NIH HHS R01 CA154643NCI NIH HHS R01 CA92153NCI NIH HHS R21 CA165923NCI NIH HHS R25 CA098566NCI NIH HHS R35 CA197449NCI NIH HHS U01 CA049449NCI NIH HHS U01 CA118444NCI NIH HHS U01 CA167552NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA186107NHGRI NIH HHS U01 HG007033NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNIA NIH HHS HHSN271201100004CNIEHS NIH HHS ES000260NIEHS NIH HHS P30 ES000260WHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004CWorld Health Organization 001
6 · The paper itself

Abstract

Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10(-11)), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10(-8)) and 3q28 (rs9815073, LPP, P=3.62 × 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 × 10(-11)) in the combined analysis. We find suggestive evidence (P<5 × 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P=7.19 × 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P=2.12 × 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.

Indexed as

Genome-Wide Association StudyAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsBcl-2-Like Protein 11Genetic Predisposition to DiseaseHumansLeukemia, Lymphocytic, Chronic, B-CellMembrane ProteinsPolymorphism, Single NucleotideProto-Oncogene ProteinsSerpinsT-Box Domain ProteinsWhite PeopleAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsBANK1 protein, humanBCL2L11 protein, humanBcl-2-Like Protein 11CSRNP1 protein, humanEOMES protein, humanMembrane ProteinsProto-Oncogene Proteinsserpin B6SerpinsT-Box Domain Proteins

Identifiers

PMID26956414
PMCPMC4786871
OpenAlexW2333739416

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.