ArticleDiagnostic pathology2016
Immunohistochemical and molecular detection of the expression of FGF23 in phosphaturic mesenchymal tumors including the non-phosphaturic variant.
Article in Diagnostic pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Real-world outcomes in patients with tumor-induced osteomalacia treated vs not treated with burosumab.Journal of the Endocrine Society · 2026Article
- Chondromyxoid fibroma with limited or no chondromyxoid stroma: A clinicopathological study of 3 cases.Virchows Archiv : an international journal of pathology · 2026Article
- Case Report: Phosphaturic mesenchymal tumor presenting solely as knee pain without hypophosphatemia.Frontiers in oncology · 2025Article
- Case Report with Literature Review: Tumor-induced osteomalacia from a soft-tissue phosphaturic mesenchymal tumor of the trunk.Frontiers in endocrinology · 2025Review
- Article
- Clinical characteristics and surgical outcomes of vertebral lesions associated with tumor-induced osteomalacia: report of 16 patients and review of the literature.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Review
- A 50-Year-Old Man Presenting with Multiple Bone Lesions and a Diagnosis of Phosphaturic Mesenchymal Tumor of the Femur.The American journal of case reports · 2024Article
- Article
- Phosphaturic Mesenchymal Tumor.AJNR. American journal of neuroradiology · 2022Article
- Management of intrathoracic phosphaturic mesenchymal tumor by nonintubated uniportal video-assisted thoracic surgery in a fragile patient.Cancer reports (Hoboken, N.J.) · 2022Article
- Phosphaturic Mesenchymal Tumor Masquerading as Mesenchymal Tumors with Diverse Differential Diagnosis: Series of 4 Cases with Emphasis on Histomorphological Spectrum.Indian journal of surgical oncology · 2021Article
- Malignant phosphaturic mesenchymal tumor-ossifying fibroma-like subtype: a case report and literature review.BMC musculoskeletal disorders · 2021Review
- A Normal FGF23 Does Not Preclude Tumor-Induced Osteomalacia.JBMR plus · 2021Article
- Tumor-Induced Osteomalacia.Calcified tissue international · 2021Review
- Clinical, histopathologic, subtype, and immunohistochemical analysis of jaw phosphaturic mesenchymal tumors.Medicine · 2020Article
- What is new about the molecular genetics in matrix-producing soft tissue tumors? -The contributions to pathogenetic understanding and diagnostic classification.Virchows Archiv : an international journal of pathology · 2020Review
- Phosphaturic mesenchymal tumor: Case report.Radiology case reports · 2019Article
- Genomic and transcriptomic characterisation of undifferentiated pleomorphic sarcoma of bone.The Journal of pathology · 2019Article
- Phosphaturic mesenchymal tumor with an admixture of epithelial and mesenchymal elements in the jaws: clinicopathological and immunohistochemical analysis of 22 cases with literature review.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2019Review
- Tumor-induced osteomalacia.Osteoporosis and sarcopenia · 2018Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhosphaturic mesenchymal tumors (PMTs) are rare neoplasms that are often associated with tumor-induced osteomalacia (TIO) due to excessive serum levels of fibroblast growth factor 23 (FGF23). PMTs share overlapping histologic features with other types of tumors; thus, accurate pathological diagnosis may be challenging. We performed an immunohistochemical examination of FGF23 expression in PMTs and other types of tumors, together with pertinent molecular analyses.
methodsSeven PMTs (5 with TIO and 2 without TIO) and 46 other types of bone and soft tissue tumors were retrieved, and immunohistochemistry was performed using a commercially available anti-FGF23 antibody. In addition, FGF23 mRNA expression was detected by reverse transcription-polymerase chain reaction (RT-PCR), using RNA extracted from formalin-fixed, paraffin-embedded tissues.
resultsImmunohistochemical analysis of FGF23 expression showed distinct, punctate staining in the cytoplasm in 5 PMTs with TIO, whereas FGF23 expression was negative in the 2 PMTs without TIO and the other 46 tumors. FGF23 mRNA expression was detected in all 4 PMTs examined, as well as in 1 chondromyxoid fibroma and 1 myxoid liposarcoma. The real-time RT-PCR data showed that the relative expression levels of the FGF23 mRNA tended to be higher in PMTs with TIO than in PMTs without TIO, or in the chondromyxoid fibroma specimen.
conclusionsOur data suggested that the feasibility of immunohistochemical detection of FGF23 may depend on the level of secreted FGF23 from tumor cells. Thus, immunohistochemistry for FGF23 is an useful diagnostic adjunct for PMT, although its utility appears to be limited in cases without TIO.
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