ArticleJournal of molecular histology2016
The effect of calcitriol on high mobility group box 1 expression in periodontal ligament cells during orthodontic tooth movement in rats.
Article in Journal of molecular histology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Role of vitamin D for orthodontic tooth movement, external apical root resorption, and bone biomarker expression and remodeling: A systematic review.Korean journal of orthodontics · 2024Article
- The Effect of Vitamin DInternational journal of dentistry · 2022Article
- High Mobility Group Box 1 Expression in Oral Inflammation and Regeneration.Frontiers in immunology · 2020Review
- Osteoprotegerin deficiency causes morphological and quantitative damage in epithelial rests of Malassez.Journal of molecular histology · 2018Article
- Effect of preameloblast-conditioned medium and CPNE7 on root surfaces in dogs: a histologic and histomorphometric evaluation.Journal of molecular histology · 2018Article
- Expression pattern of YAP and TAZ during orthodontic tooth movement in rats.Journal of molecular histology · 2018Article
- Tension force-induced bone formation in orthodontic tooth movement via modulation of the GSK-3β/β-catenin signaling pathway.Journal of molecular histology · 2018Article
- Mechanical stress promotes matrix synthesis of mandibular condylar cartilage via the RKIP-ERK pathway.Journal of molecular histology · 2017Article
- CTHRC1 promotes osteogenic differentiation of periodontal ligament stem cells by regulating TAZ.Journal of molecular histology · 2017Article
- Effect of corticision on orthodontic tooth movement in a rat model as assessed by RNA sequencing.Journal of molecular histology · 2017Article
- Histological evidence that metformin reverses the adverse effects of diabetes on orthodontic tooth movement in rats.Journal of molecular histology · 2017Article
- Wnt5a mediated canonical Wnt signaling pathway activation in orthodontic tooth movement: possible role in the tension force-induced bone formation.Journal of molecular histology · 2016Article
- Tooth loss caused by displaced elastic during simple preprosthetic orthodontic treatment.World journal of clinical cases · 2016Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High mobility group box 1 (HMGB1) is a late inflammatory cytokine that plays an important role in periodontal tissue remodeling during orthodontic tooth movement. Calcitriol (1,25-dihydroxyvitamin D3 [1α,25 (OH)2D3]) is a systemic calcium-regulating hormone shown to downregulate expression of multiple proinflammatory cytokines in human periodontal ligament cells in response to orthodontic force. The purpose of this study was to investigate the effect of 1α,25(OH)2D3 on the expression of HMGB1 in periodontal ligament (PDL) cells during orthodontic tooth movement. Seven-week-old male Wistar rats were used for experimentation. Tooth movement was assessed using a nickel-titanium coil spring to apply mechanical loading to the tooth for 5 days. This was followed by administration of either 1α,25(OH)2D3 or normal saline by gavage every other day for up to 28 days. Immunohistochemistry was used to analyze the expression of tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6 and HMGB1. After discontinuation of orthodontic force, expression of the early inflammatory cytokines IL-6 and TNF-α were time-dependently reduced in the 1α,25(OH)2D3 group compared with the control group at each time point. Similarly, expression of HMGB1 was decreased over time in both the 1α,25(OH)2D3 and normal saline groups, and 1α,25(OH)2D3 administration enhanced this decline. These findings indicate that administration of 1α,25(OH)2D3 might provide a favorable microenvironment for orthodontic tooth movement by downregulating expression of HMGB1 in PDL cells.
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